• Pain flare defined as a temporary worsening of bone pain

  2019-07-01

  

  Pain flare, defined as a “temporary worsening of bone pain in the treated metastatic site” [2], has been previously documented as a side effect of radiopharmaceutical and hormonal therapy [2,10,11]. Although it is a recognized side-effect of radiation treatment as well, only recent studies have att

• br Conflict of interest br Authors contributions

  2019-07-01

  

  Conflict of interest Authors’ contributions Acknowledgements Introduction Aromatase-Inhibitors (AIs) are commonly used in the treatment of post-menopausal women with a history of hormone receptor-positive breast carcinoma, and have been shown to decrease bone mineral density (BMD) and in

• A substantial body of evidence linking inflammation to the p

  2019-07-01

  

  A substantial body of evidence linking inflammation to the pathophysiology of a broad spectrum of cardiovascular diseases, including coronary artery disease, diabetes mellitus, and hypertension, has been developed [8–11]. Similarly, the hypothesis that inflammatory processes are involved in the path

• br Genetic basis for atrial

  2019-07-01

  

  Genetic basis for atrial standstill Genetic basis of conduction block Genes involved in cardiac development and bradycardia Development of the CCS is a complex biological process with the potential to be wrought with problems. Several transcription factors, including homeodomain proteins an

• Introduction Catheter ablation of accessory pathways APs

  2019-07-01

  

  Introduction Catheter ablation of accessory pathways (APs) can be challenging depending on the location of the AP. Anteroseptal APs are rare but associated with lower success rates and higher incidence of atrioventricular (AV) block [1,2]. Data regarding the electrocardiographic and electrophysiolo

• br In Anand Bhopal s discussion March

  2019-07-01

  

  In Anand Bhopal\'s discussion (March, 2015) of health inequalities, social determinants of health, and advocacy for social change in health care in the 21st century, we were disappointed to see little recognition of the branch of medicine that dnmt epitomises “societal doctors”: public health. A

• Sirtinol En la condensaci n del Borges y yo

  2019-07-01

  

  En la condensación del “Borges y yo” se despliega un texto que tanto puede ser considerado perteneciente al orden de la narrativa como al orden del ensayo, e incluso al de la poesía. En palabras de José Miguel Oviedo, “es un cuento que es también un ensayo que es también un poema”. “No sé quién de l

• br Conflict of interest statement br

  2019-06-29

  

  Conflict of interest statement Acknowledgement We thank the constant support of nanomedicine research from the Ming Hsieh Institute for Research on Engineering-Medicine for Cancer. The authors certify that they have no affiliations with or involvement in any organization or entity with any fin

• br Discussion Early repolarization is a common ECG character

  2019-06-29

  

  Discussion Early repolarization is a common ECG characteristic. Its reported prevalence is 6–25% of the general population, and is particularly common in athletes [2,3,11,12]. It is now recognized that a small fraction of people with early repolarization on their ECGs develop lethal tachyarrhythm

• Examples of numerically generated vortices and their organiz

  2019-06-29

  

  Examples of numerically generated vortices and their organizing centers in 3-D excitable media are illustrated in Fig. 1. Panels a to d show 4 different configurations of 3-D scroll waves that were computed using the FitzHugh–Nagumo model [39,40]. Panel a shows an example of the simplest configurati

• useful site br Conflict of interest br Introduction

  2019-06-29

  

  Conflict of interest Introduction Histopathology involves the use of dyes for microscopic examination of tissues in part to spot signs and characteristic features of diseases. Recently, computer assisted diagnosis (CAD) has been widely used in developed countries. In general, it is well-recogn

• Cell adhesion to extracellular matrix requires the interacti

  2019-06-29

  

  Cell adhesion to extracellular matrix requires the interaction of different molecules like selectins, cadherins and integrins [21]. Especially αvβ3 integrin has been proposed to mediate the adhesion of malignant cells in different entities such as multiple myeloma and breast cancer [22,23]. Upon exp

• Several anti platelet therapies have been evaluated in

  2019-06-29

  

  Several anti-platelet therapies have been evaluated in the context of bone metastasis. In vitro, a dual anti-platelet treatment using the soluble ADPase APT102 and an inhibitor of TxA2 synthesis (Aspirin) markedly affected tumor cell-induced platelet aggregation without altering tumor cell viability

• br Future perspectives Identification of LOX as

  2019-06-29

  

  Future perspectives Identification of LOX as a modulator of the ECM to form pre-metastatic niches and subsequently bone metastasis arose as we were investigating the hypoxia tumour secretome using existing patient cohort data and cutting edge proteomics. Although condoned by some researchers as “

• This is similar to the z score with the

  2019-06-29

  

  This is similar to the z score, with the mean intra-sample correlation providing a “population mean”. A score greater than −1 was considered a good match (1 point), a score greater than −2 was a partial match (0.5 points), and a score less than −2 was no match (0 points). Spatial resolution was then

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