• Introduction Human embryonic stem cells hESCs which

  2018-10-29

  

  Introduction Human embryonic stem cells (hESCs), which are derived from the inner cell mass of blastocysts, exhibit unique features including pluripotency, self-renewal and the capacity to differentiate into three germ layers both in vitro and in vivo (Thomson et al., 1998). Several previous studi

• To define the transcriptome of the

  2018-10-29

  

  To define the transcriptome of the ExE lineage in the present study, we analyzed primitive endoderm and trophectoderm markers using qRT-PCR. Interestingly, we found that markers of the primitive endoderm, such as DDAH2, LAMB1, DAB2, AFP and NR2F1 (COUP-TF1), and markers of the trophectoderm, such as

• Our observation of different rates

  2018-10-29

  

  Our observation of different rates of proliferation in the basal cell layer of tail IFE is consistent with earlier findings (Mascré et al., 2012). However, this difference is not due to slow-cycling stem gtpase giving rise to rapidly cycling committed progenitors (Mascré et al., 2012). Instead, sca

• Our observations are consistent with previous findings in vi

  2018-10-26

  

  Our observations are consistent with previous findings in vivo that Ahr expression is silenced at the 2-cell stage, becoming again detectable in late blastocysts (Peters and Wiley, 1995; Dey and Nebert, 1998; Wu et al., 2002) and in most developing organs during post-implantation development (Abbott

• The importance of the finding that the prostaglandin pathway

  2018-10-26

  

  The importance of the finding that the prostaglandin pathway is selectively downregulated by MSX2, but not MSX1, is 2-fold; i) this functional disparity between MSX1 and MSX2 provides a mechanistic insight into a cellularization event during muscle dedifferentiation and ii) it also demonstrates that

• Raman microspectroscopy is a marker free method that

  2018-10-26

  

  Raman microspectroscopy is a marker-free method that can be used to characterize single cells based on a pattern of molecular vibrational modes, which reflects the composition of intracellular proteins, lipids, nucleic acids, and exactly (Puppels et al., 1990). Notingher et al. (2004) investigated

• Here we describe the generation of

  2018-10-26

  

  Here we describe the generation of the first L-MYC-immortalized human NSC line derived from human fetal brain, for brevity referred to as LM-NSC008. We find that the LM-NSC008 line is chromosomally normal, and overexpresses several stem cell-associated genes. LM-NSC008 cells proliferate faster than

• Practical considerations limit the use of autologous

  2018-10-26

  

  Practical considerations limit the use of autologous NSCs for cell-based therapy. Allogeneic donor cells remain an attractive possibility if an appropriate source can be identified. Although the self-renewing NSCs present in developing description tissue could be used as a renewable cell population

• br Summary The total thermal

  2018-10-26

  

  Summary The total thermal resistance of the LED and its components were determined from the measurements of transient temperature-sensitive characteristics (forward voltage ) of the chip under a step-like drive of heating current. The total thermal resistance of the LED is found to grow by about

• Our analyses also show that those born to

  2018-10-26

  

  Our analyses also show that those born to young and older mothers are more likely to smoke, and to consume alcohol regularly, while those born to older mothers are less likely to exercise regularly, even after adjusting for parental SES, socio-demographic characteristics, and self-reported depressio

• Models and focus on educational

  2018-10-26

  

  Models 4 and 5 focus on educational differentials in health. First, Model 4 shows a positive association between higher education and good SRH. Then, random effect of education, estimated with a cross-level interaction (education×year), is reported in the bottom of Model 5. Random effect of educatio

• Broader understanding of pathways of influence could also in

  2018-10-26

  

  Broader understanding of pathways of influence could also inform intervention development. A walking intervention involving the installation of walking route signage and leadership for local walking groups in two low-income neighbourhoods in Ireland had only a marginal effect on physical activity (B

• We found little consistency in how adolescent neighbourhood

  2018-10-26

  

  We found little consistency in how adolescent neighbourhood social environments have been both conceptualised and operationalised. When operationalised the various concepts of adolescent neighbourhood measures were largely indistinct. Again, this is similar to findings from the previous review by Sa

• br Literature review br Research

  2018-10-26

  

  Literature review Research design Analysis and results The data analysis will consist of exploring the statistical properties of all the items of the scales and testing the validity and reliability of the constructs (Gallarza & Gil, 2006). We will verify the reliability through the inter-it

• Risk behaviours are important threats during adolescence due

  2018-10-26

  

  Risk behaviours are important threats during adolescence due to possible lifetime negative consequences. Their prevalence is high in the USA: the percentage of those who ever smoke, drunk, use marijuana and cocaine was respectively 44.7, 70.6, 39.9 and 18.2% in a national survey; the percentages of

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