• Financial leverage RSK is employed

  2018-11-03

  

  Financial leverage (RSK) is employed in the literature (e.g., Waddock & Grave, 1997) as a proxy for the risk. It is used to reflect management׳s risk tolerance that flap inhibitor influences its attitude towards social activities and measured by the ratio of total debt to total assets. Dividend per

• br Introduction br Climate specific building

  2018-11-03

  

  Introduction Climate specific building design principles The first step is the optimization of the efficiency of the building envelope. This can be achieved by adequate insulation, air-tightness and optimized glazing, which allows the passive use of solar gains in cold climates or limiting sol

• The term vapour retarder is

  2018-11-03

  

  The term “vapour retarder” is somewhat undefined. The broadest definition could be that a vapour retarder is less vapour tight than the minimum recommendation for vapour barriers and more vapour tight than the maximum recommendation for wind barriers. According to Norwegian recommendations this wou

• These results showed that the intensities of solar

  2018-11-02

  

  These results showed that the intensities of solar radiation incidence on the roof varied depending on the colour and thermo-physical properties of the roof. Givoni (1994) showed that the the difference in the maximum external surface temperature between a black and white roof in the desert during s

• The following factors are provided Al Homoud to be considere

  2018-11-02

  

  The following factors are provided (Al-Homoud, 2001) to be considered when selecting a method/tool for performance analysis: (1) accuracy, (2) sensitivity, (3) speed and cost of learning and use, (4) reproducibility, (5) ease of use and detail level, (6) availability of required date, (7) output qua

• br Materials and methods br

  2018-11-02

  

  Materials and methods Statistical analysis The statistical end point of the analyses was the disease-free survival (DFS) from the date of surgery. Group distributions for each clinicopathologic trait were compared using two-tailed Fisher\'s exact procedure and the chi-square test. Numerical va

• Current evidence indicates that the main reservoirs of zoono

  2018-11-02

  

  Current evidence indicates that the main reservoirs of zoonotic Cryptosporidium remain livestock, with the potential transmission of C. parvum (= C. pestis (see Slapeta, 2011)), although other species, and genotypes, have been reported in humans but only occasionally (Slapeta, 2013). Susceptibility

• Several culture techniques have been developed for

  2018-11-02

  

  Several culture techniques have been developed for ex vivo expansion of limbal epithelial cells, including those that used intact or denuded AM as a supporting matrix; adopted an airlifting technique to promote epithelial differentiation; and prepared 3T3 fibroblasts as feeder layers (Sun et al., 20

• GSK2656157 Although our report mainly focuses on the

  2018-11-02

  

  Although our report mainly focuses on the generation of clinical-grade hESCs, transplantation safety is also a concern. For example, a 9-year-old boy was diagnosed with a glioneuronal neoplasm after being transplanted with neural stem GSK2656157 derived from two donors (Amariglio et al., 2009). Alt

• For ESCs on the other

  2018-11-02

  

  For ESCs, on the other hand, we and others recently established that single factors, such as neurogenic differentiation factor 1 (NEUROD1) or neurogenin 2 (NGN2), alone are sufficient to rapidly induce the neuronal fate (Thoma et al., 2012; Zhang et al., 2013). In fibroblasts, however, we had origin

• Taken together our results demonstrate an essential role for

  2018-11-02

  

  Taken together, our results demonstrate an essential role for STAT5 in the regulation of adult IESC homeostasis and response to intestinal injury and regeneration. Functionally, genetic activation of Stat5 increases IESC regeneration to replenish injured intestinal epithelia, conferring resistance t

• The addition of only g ml rBC LCN PE

  2018-11-02

  

  The addition of only 10 μg/ml rBC2LCN-PE23 to the culture medium was sufficient to completely eliminate hiPSCs after 24 hr, even in a mixed cell population. The dispersion of colonies was not a prerequisite to induce cell death of hiPSCs, demonstrating the high permeation ability of the developed re

• The creation and maintenance of subcutaneous patient derived

  2018-11-02

  

  The creation and maintenance of subcutaneous patient-derived xenografts (PDX) from fresh or cryopreserved ACC tissue (Moskaluk et al., 2011) provided a renewable source of ACC read the article for validation of our CSC hypothesis. As we previously demonstrated, these PDX models reproduced ACC morph

• In this study we describe an efficient dCas

  2018-11-02

  

  In this study, we describe an efficient dCas9 activator with multimeric VP16 activation domain and a simplified method for guide RNA assembly and cloning. We demonstrate that the dCas9 activator can be fused to a dihydrofolate reductase (DHFR)-derived destabilization domain (DD) (Iwamoto et al., 201

• The ISSCR has recently released updated guidelines on stem

  2018-11-02

  

  The ISSCR has recently released updated guidelines on stem cell research and clinical translation (Daley et al., 2016; ISSCR, 2016) that stress the importance of rigorous preclinical testing and recommends the publication of preclinical studies in full to allow assessment of the strength of the evid

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