• In this study we used dermal fibroblasts

  2018-10-22

  

  In this study we used dermal fibroblasts derived from three different patients with distinct mutations in the TAZ1 gene (Houtkooper et al., 2009) and generated BTHS patient-specific iPSCs. We fully characterized them in terms of pluripotency both in vitro and in vivo. Similar to human ESCs, all gene

• In contrast it is very surprising

  2018-10-22

  

  In contrast, it is very surprising that N-cad can confer a compact ES cell phenotype and is capable of participating in the MET process in our gene replacement approach. With the exception of its expression in the pseudostratified neuroepithelium, N-cad is usually associated with a mesenchymal unpol

• AG 013736 An often overlooked aspect of

  2018-10-20

  

  An often overlooked aspect of neurotoxicity is the impact of chemicals, as well as drugs and drug candidates, on neural stem AG 013736 and their terminally differentiated lineages. Stem cells have been shown to exhibit differential sensitivities to both non-toxic (e.g., serum) and toxic compounds,

• In the experiments described in this report molecular and

  2018-10-20

  

  In the experiments described in this report, molecular and cellular processes downstream of SOX18 were studied in a non-endothelial background. Effects of SOX18 expression on ASCs were manifested in an endothelial-like cell morphology and responsiveness to forces exerted by laminar flow. SOX18 induc

• br Introduction Thyroid hormone TH is a critical regulator o

  2018-10-20

  

  Introduction Thyroid hormone (TH) is a critical regulator of many physiological and developmental processes, following its activation from the stable prohormone (l-thyroxine, T4) to the short-lived active hormone, triiodothyronine (3,5,3′-triiodo-l-thyronine, T3) (Fig. 1). T3 induces amphibian me

• br Methods and materials br Results br

  2018-10-20

  

  Methods and materials Results Discussion In vitro differentiation of ESCs closely mimics early embryonic development and can produce large quantity of hematopoietic cells. However, segregation of the EryPs from surrounding purchase INNO-406 differentiated from mESCs has not been reported. H

• br Acknowledgments This work was funded by

  2018-10-20

  

  Acknowledgments This work was funded by operating grants to C.M.M. from the Canadian Institutes of Health Research (CIHR) (CIHR-NCE - 72041182) and the Heart and Stroke Foundation of Canada (H&S - 72043144). A.C. is a recipient of the Ontario Graduate Scholarship award. Introduction Neural st

• Fortunately a new class of RNA guided nucleases has

  2018-10-20

  

  Fortunately, a new class of RNA-guided nucleases has been developed from microbial adaptive immune systems (i.e. clustered regularly interspaced short palindromic repeat-CRISPR- and CRISPR associated Cas9-CRISPR/Cas9-systems) (Cong et al., 2013; Mali et al., 2013a). This system provides a very simpl

• In addition to supplying a source of growth factors

  2018-10-20

  

  In addition to supplying a source of growth factors and signaling molecules, blood vessels also provide a physical framework that can support the migration of neural progenitors during development and in the adult aa utp (Whitman et al., 2009). In the embryonic and adult rodent SVZ, newly born prog

• br Materials and methods br Results br Discussion The

  2018-10-20

  

  Materials and methods Results Discussion The effect of donor MSCs in tumor growth remains controversial (Cho et al., 2009). Discrepancies concerned to whether they promote or suppress it may be due to disparities in cell source, isolation and expansion conditions, via and timing of administ

• We initially tested this system s capacity to induce epigene

  2018-10-20

  

  We initially tested this system’s capacity to induce epigenetic reprogramming toward the SkM lineage in C3H10T1/2 kanamycin previously shown to readily undergo this transformation (Davis et al., 1987). We designed three separate gRNAs (1–3) targeted to different positions proximal to the Myod1 trans

• Cell cycle adaptations in human ESCs

  2018-10-20

  

  Cell-cycle adaptations in human ESCs (hESCs) are less defined. In contrast to mESCs, hESCs exhibit significant fluctuation of cyclin expression in a cell-cycle-dependent manner (Neganova et al., 2009), indicating differences in the regulation of key cell-cycle proteins between the two cell types. Si

• Human embryonic stem cells hESCs the in vitro representation

  2018-10-20

  

  Human embryonic stem ion channels (hESCs), the in vitro representation of the human epiblast (Thomson et al., 1998), enable unique access to the spontaneous emergence of the three embryonic germ layers in culture (Itskovitz-Eldor et al., 2000), providing an opportunity to model and manipulate the ea

• br Results The levels of TGF

  2018-10-20

  

  Results The levels of TGFβ and downstream signaling mediators (activated SMAD2/3) increase in muscle of dystrophic mdx mice with age, correlating to reduced regeneration, angiogenesis and function, and higher fibrosis extent (Ardite et al., 2012; Kharraz et al., 2014; Mann et al., 2011; Vidal et 

• The present study showed that transplantation of iBAs and dB

  2018-10-20

  

  The present study showed that transplantation of iBAs and dBAs markedly reduced diet-induced obesity, dyslipidemia, and insulin resistance in mice (Figures 2, 6, and 7). The dBAs controlled insulin resistance in an UCP1-dependent fashion, strongly suggesting the UCP1-mediated energy expenditure as t

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