• Fourth non canonical sites may be targeted Classical benzodi

  2024-06-18

  

  Fourth, non-canonical sites may be targeted. Classical benzodiazepines require the presence of a γ subunit for high-affinity binding, which limits their activity to a specific large pool of receptor isoforms, leaving other isoforms unaffected. In particular, δ subunit-containing receptors, as well a

• Hypoxia of the adipose tissue is a key step in

  2024-06-18

  

  Hypoxia of the adipose tissue is a key step in the inflammatory response linked to obesity and contributes to accelerated tumor progression in the obese population (Rosenow et al., 2013). Intermittent hypoxia exposure induces a 2.2-fold increase in the infiltration of tumor-associated macrophages an

• lasofoxifene receptor Acknowledgments br Introduction Pulmon

  2024-06-18

  

  Acknowledgments Introduction Pulmonary fibrosis (PF) is a chronic, fibrosing interstitial pneumonia and a crushing disease that occurs as a result of a variety of lung injuries, including auto-immune, tuberculosis and traumatic insult [1], [2]. PF is characterized by the accumulation of extracel

• EPSP analogs were retrieved from PubChem database and dockin

  2024-06-18

  

  EPSP analogs were retrieved from PubChem database and docking procedure yielded about eight best binding analogs (Fig. 10). The selected molecules were further assessed for their theoretical Ki values using AUTODOCK software version 4. The predicted binding efficiency of retrieved analogs was estima

• The sequential behavioral approach used in

  2024-06-18

  

  The sequential behavioral approach used in the present study reinforced the involvement of the BDNF/TRKB system in the effect of losartan. In mice with dampened BDNF expression, losartan was no longer able to exert antidepressant-like effects. Similar to what was observed after losartan treatment, t

• br Summary and future br Introduction

  2024-06-18

  

  Summary and future Introduction Androgen activity is critical for a wide range of developmental and physiological responses and is especially important in male sexual differentiation and maturation. The biological activity of androgens occurs through binding to the androgen receptor (AR) and t

• In view of the ubiquitous distribution of the arachidonate

  2024-06-18

  

  In view of the ubiquitous distribution of the arachidonate 12S-lipoxygenase isoforms and the variety of cellular reactions influenced by the resulting arachidonate metabolites, these products widely play important roles in many biological systems. The development of new type-specific inhibitors of t

• One study has demonstrated that PUFA reduced both

  2024-06-17

  

  One study has demonstrated that ω-3 PUFA reduced both cholesterol and caveolin-1 (a marker of raft), thereby displacing raft-associated signaling molecules from lipid raft [36]. Additionally, DHA treatment decreased the amount of lipid raft in the cell surface and displaced several lipid raft-associ

• The structure of LO is divided in two

  2024-06-17

  

  The structure of 5-LO is divided in two domains, the catalytic C-terminal domain and the N-terminal regulatory C2-like domain (C2ld) [59,60]. The C2ld spans the 4-Methylhistamine dihydrochloride 1-114 and is responsible for translocation and binding of calcium and membranes [61–63]. The catalytic d

• br Methods br Results br Discussion br Acknowledgements br

  2024-06-17

  

  Methods Results Discussion Acknowledgements This work was supported by the National Institutes of Health [Grant R21 NS081429], a Pilot Grant from the Vanderbilt Conte Center supported by the National Institutes of Health [Grant P50 M096972], and by the Department of Anesthesiology at V

• Steroidal CYP inhibitors can further be

  2024-06-17

  

  Steroidal CYP17 inhibitors can further be classified based on their mode of action, namely as mechanism-based inhibitors and type I and type II competitive inhibitors [129]. Recent studies investigated other biological targets than CYP17, and some new compounds have shown interesting dual activity a

• However cancer and fibrotic diseases are

  2024-06-17

  

  However, cancer and fibrotic diseases are the most extensively studied disease states. ATX is connected to various cancers because it can stimulate chemokinesis and chemotaxis in melanoma cells. Upregulated ATX inhibitor of apoptosis proteins has been reported in breast cancer,, prostate cancer, t

• The Kelch like ECH associated protein

  2024-06-17

  

  The Kelch-like ECH-associated protein 1 (Keap1)-Nrf2 signaling pathway functions as one of the key regulator of the cellular defense system against oxidative stress [26]. Nrf2 is a redox-sensitive transcription factor, that is sequestered in the cytoplam by binding to Keap1; however, under oxidative

• br Acknowledgements br Introduction Thus damage to the

  2024-06-17

  

  Acknowledgements Introduction Thus, damage to the gtpase may produce severe consequences (National Research Council, 1992). Indeed, though the nervous system has several compensatory and adaptive mechanisms, it is vulnerable to toxic insult, due to its inability to regenerate after lethal dam

• ATM is generally regarded to be the principal mediator of

  2024-06-17

  

  ATM is generally regarded to be the principal mediator of the G1 Sodium valproate checkpoint, whereas the induction of the intra-S-phase and G2/M checkpoints are usually primarily related to ATR function. However, several studies have demonstrated that, depending on the cellular context and type of

15903 records 123/1061 page Previous Next First page 上5页 121122123124125 下5页 Last page