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In the mammalian brain synapse
2023-01-09
In the mammalian brain, synapse formation is followed by a period of synapse refinement, and autophagy has been shown to play an important role in this process. For example, Tang and colleagues found that autophagy is required for the developmental pruning of dendritic spines, and that this pruning
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To further evaluate the influence of antibiotics
2023-01-09
To further evaluate the influence of Heparin sodium on allergy, Russel et al. initiated vancomycin treatment during pregnancy in mice and continued it for several weeks after birth. This resulted in exaggerated OVA-induced allergic inflammation, characterized by higher numbers of lung eosinophils,
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br Economics consequences of antibiotic
2023-01-09
Economics consequences of antibiotic resistance in a SICU In the era of cost-containment, surgeons also need to consider the economic impact of antibiotic resistance in the surgical patient. Antibiotic-resistant infections are more difficult to treat, are more costly and more likely to be fatal t
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Angiogenesis refers to the formation of new blood vessels
2023-01-09
Angiogenesis refers to the formation of new blood vessels from pre-existing vasculature [1]. Physiological angiogenesis is necessary for key processes such as wound healing, tissue regeneration and repair. In pathological conditions, including cardiovascular diseases, diabetes, cancer, and other pat
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Kim et al found that hydroxydopamine
2023-01-09
Kim et al. (2013) found that 6-hydroxydopamine (6-OHDA) promoted the atrophy of dopaminergic neurons associated with the activation of poly (ADP-ribose) polymerase (PARP), the translocation of apoptosis inductor factor (AIF) and the depletion of ATP. An increase in p-AMPK and pS6K (upstream kinase o
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Recent genome wide association studies have indicated SORL a
2023-01-09
Recent genome-wide association studies have indicated SORL1 as a risk factor for AD (Meng et al., 2007, Rogaeva et al., 2007, Wen et al., 2013). SORL1, is expressed in neurons (Yin et al., 2015) and also regulates APP traffic from the cell membrane to the Golgi apparatus. A reduction in its expressi
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br Results and discussion The
2023-01-05
Results and discussion The morphology and structure of 520 3 samples were observed using an SEM, as shown in Fig. 1. The length and thickness of the actin filaments were regulated with ABPs to mimic the various actins observed in cells. We prepared three types of F-actin with or without gelsolin
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br Regulation and pharmacology of mPGES
2023-01-05
Regulation and pharmacology of mPGES-1 mPGES-1 (16 kDa, 152 amino acids) is a trimeric integral membrane protein of the endoplasmic reticulum with each monomer containing four transmembrane domains (Samuelsson et al., 2007; Sjogren et al., 2013). The three active site cavities are located at the
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Whereas more research is needed to identify the precise mech
2023-01-05
Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the how to calculate molar concentration that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN co
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In this scenario the receptor tyrosine kinase inhibitors TKI
2023-01-05
In this scenario, the receptor tyrosine kinase inhibitors (TKI), sunitinib, an anti-angiogenic agent, was tested in phase III trial, leading to a longer progressing free survival when compared to interferon (median: 11 vs. 5mo, respectively, hazard ratio (HR) = 0.42; 95% CI: 0.32–0.54; P select and
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The amino hydroxy methyl isoxazolepropionic acid AMPA recept
2023-01-05
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic haloperidol haldol (AMPA) receptor is also enriched in postsynaptic striatal neurons (Bernard et al., 1997, Kondo et al., 2000, Reimers et al., 2011). Its activity is subjected to the regulation by a mechanism involving phosphorylation (Lu and Roc
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Although the LB domains of
2023-01-05
Although the LB2 domains of mGlu receptors have not been shown to form an extensive interface during activation, they do draw closer to each other, as demonstrated in crystal structures (Kunishima et al., 2000, Muto et al., 2007, Tsuchiya et al., 2002) and by FRET analysis (Doumazane et al., 2013, V
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The use of FTAI can overcome
2023-01-05
The use of FTAI can overcome the negative impact of low estrus detection efficiency, but implies effective synchrony of luteal function as well as synchronous growth and ovulation of a viable Cabazitaxel synthesis follicle. Pregnancy rates obtained with FTAI may be comparable or better than those ob
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Using the same techniques we found that
2023-01-05
Using the same techniques, we found that UCP3 also has a half-life of between 1 and 4h [117]. In Pleuromutilin to UCP2 and UCP3, UCP1 and ANT had much longer half-lives and could not be degraded in the cell-free reconstituted system, suggesting their degradation is not mediated by the cytosolic pro
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The number of times an animal reared
2023-01-05
The number of times an animal reared was the only emotional behavior that was significantly higher in the young mice than in the middle-aged group. This may be explained by diminished curiosity or augmented ambulation with aging (Lalonde and Strazielle, 2008). A recent study showed that middle-aged
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