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Whether histamine receptor distribution is altered
2022-05-27
Whether histamine receptor distribution is altered in canine GI diseases remains unknown, but human research has documented altered histamine receptor density in certain GI diseases (Sander et al., 2006, Deiteren et al., 2015, Von Rahden et al., 2011). Additionally, a novel H4 receptor antagonist, J
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In this study we also profiled the
2022-05-27
In this study, we also profiled the expression of the transporters in wild-type RBL-2H3 cells, RBL-2H3 Sc98 cells, and rat peritoneal mast cells. OCT1 and PMAT were expressed at high levels in both RBL-2H3 Sc98 and RBL-2H3 cells. However, OCT2 and OCT3 were weakly or least detected in RBL-2H3 Sc98 c
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br Conclusion br Disclosure of interest
2022-05-27
Conclusion Disclosure of interest Acknowledgement Introduction Vitamin B6 has long been recognized as a cofactor for many enzymes, especially those involved in amino MK-1775 australia metabolism. Apart from its role as coenzyme, recent studies are unveiling a new role of vitamin B6 as a
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An interesting question is why RhoF
2022-05-27
An interesting question is why RhoF has such the slow rate of GDP dissociation. The amino Epibrassinolide mutations in a presumable GDP-binding site of RhoF had only moderate effects on the GDP dissociation (Fig. 3C), which suggests a mechanism involving the global amino acid sequence of RhoF, rath
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(±)-Baclofen Several groups studied CTD mouse
2022-05-26
Several groups studied CTD mouse models, which largely mimicked the symptoms (i.e. impaired cognition and autistic-like behaviour) of the human disease (Kurosawa et al., 2012; Baroncelli et al., 2016; Stockebrand, 2018). The CRT-1 knockout mice showed a drastic deterioration in the GABAergic system,
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Epalrestat br Inclusion exclusion criteria br Quality assess
2022-05-26
Inclusion/exclusion criteria Quality assessment All studies included in the qualitative synthesis were evaluated using the Quality Assessment Tool for Quantitative Studies (QATQS), which allows to determine their methodological quality. QATQS assesses 8 sections: selection bias, study design,
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Based on the molecular weights
2022-05-26
Based on the molecular weights of glutamate (147.13 g/mol) and MSG (169.111 g/mol), the amount of free glutamate intake obtained in this study was equivalent to 297 mg MSG/d and 370 mg MSG/d for children and adults, respectively. Several previous studies have assessed population intake of MSG from f
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br Discussion Our results indicate that
2022-05-26
Discussion Our results indicate that marked changes in the relative distribution of AMPA receptors in microsomal and synaptic fractions occur during the postnatal period, and that these changes are correlated with changes in different populations of AMPA binding sites. At early postnatal ages (PN
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br Acknowledgments This research was supported
2022-05-26
Acknowledgments This research was supported by a grant from the Korea Health Technology R&D Project through the Korean Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI17C0616). Dr. Jun-Mo Yang was supported by the Natio
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However it is unclear whether the
2022-05-26
However, it is unclear whether the parent and transition metal substitution in Keggin-type phosphomolybdic dexamethasone acetate will reveal the best effects on α-glucosidase. Therefore, the Keggin-type H3PMo12O40 (abbreviated as PMo12) and three transition metal-substituted POMs (Na4PMo11VO40, Na6P
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Limitations of our study are the
2022-05-26
Limitations of our study are the following: we did not measure central energy metabolism in parallel, so we can only hypothesize that GLUT1 hypermethylation may be associated with alterations in central glucose metabolism. We did not measure GLUT1/GLUT4 gene expression or glucose uptake, so that we
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br Introduction Glucokinase GCK hexokinase IV
2022-05-26
Introduction Glucokinase (GCK, hexokinase IV) is a monomeric enzyme that catalyzes the ATP-dependent conversion of glucose to glucose 6-phosphate, the first and rate-limiting step of glycolysis in the liver and pancreas [1,2]. GCK was first discovered in the early 1960's, and shortly thereafter i
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br Author contributions br Transparency document br Acknowle
2022-05-26
Author contributions Transparency document Acknowledgments The financial contributions of the Marie-Curie Action: BIOCONTROL, contract number MCRTN – 33439, the Agence Nationale de la Recherche (projects membraneDNP 12-BSV5-0012, MemPepSyn 14-CE34-0001-01, InMembrane 15-CE11-0017-01 and the
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Gal is a amino acid residue peptide comprising amino
2022-05-26
Gal is a 29-amino map3k8 residue peptide, comprising 30 amino acids in humans, isolated from the porcine intestine 30 years ago (Tatemoto et al., 1983). It has been shown to be involved in the regulation of numerous processes, including neuroendocrine control of systems such as the hypothalamic–pit
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Determination of enzyme activity differs from other analytic
2022-05-26
Determination of enzyme activity differs from other analytical procedures. In this ampk inhibitors case, instead of enzyme concentration, a substrate depletion or product accumulation should be monitored. Such approach allows calculating activity basis of calibration curves performed for enzymatic
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