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Platycodon grandiflorum is a member of the genus Platycodon
2022-01-10
Platycodon grandiflorum is a member of the genus Platycodon and is commonly known as balloon flower. In East Asia, P. grandiflorum is used for the treatment of asthma, coughs, inflammatory diseases, pulmonary tuberculosis, and diabetes (Takagi and Lee, 1972). Furthermore, recent studies have reporte
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Before cell motility assay cells were pretreated with
2022-01-10
Before cell motility assay, A-674563 receptor were pretreated with GW1100 (1 μM), which is an antagonist of GPR40 [20], [21]. GW1100 increased the cell motile activity of MG63-R7 cells in the presence of GW9508, similar as observed with MG-63 cells (Fig. 4A). Moreover, to confirm the effects of GPR
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Indeed in women with different causes of epithelial layer
2022-01-10
Indeed, in women with different causes of epithelial layer damage, HIV infection rates have been reported to be very high [2], [3]. As observed from in vivo studies, disruption of the epithelium due to pathogens [45], [46] or chemical irritants [47], has resulted in women being at a higher risk of H
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Because HIV does not infect neurons the neurotoxicity in HAN
2022-01-10
Because HIV does not infect neurons, the neurotoxicity in HAND is thought to result from the neuroinflammation evoked by the release of viral proteins and cytokines from infected microglia and macrophages (Ellis et al., 2007; Saylor et al., 2016). Viral tropism is determined by gp120 binding to CD4
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br Introduction Herpes viruses are
2022-01-07
Introduction Herpes viruses are members of Herpesviridae family. This family consists of DNA viruses and it is a very large family. The viruses related to this family cause many diseases in animals and humans [1]. Herpes simplex viruses cause mucocutaneous lesions in the affected humans. These le
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br Inclusion exclusion criteria br Quality assessment
2022-01-07
Inclusion/exclusion criteria Quality assessment All studies included in the qualitative synthesis were evaluated using the Quality Assessment Tool for Quantitative Studies (QATQS), which allows to determine their methodological quality. QATQS assesses 8 sections: selection bias, study design,
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Fig A demonstrates the body weight
2022-01-07
Fig. 2A demonstrates the body weight gain of the pregestational females. High-fat diet in wild-type mice increased body weight in 2 weeks and sustained this increase over 8 weeks. A similar effect was noted in glut3 mice in response to a high-fat diet. Fig. 2B depicts fat and muscle mass as assessed
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Meanwhile a myriad of studies using
2022-01-07
Meanwhile a myriad of studies using tissue- and cell type-specific deletion of GPX4 have provided evidence that various tissues/cells, such as distinct neuronal cell populations including glutamatergic neurons of the forebrain [24], Purkinje cells of the cerebellum [74] and motor neurons [75], photo
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br Promotion of GLS expression
2022-01-07
Promotion of GLS2 expression Glutamine metabolism is another target for alteration in ferroptosis. Glutamine is required for the induction of ferroptosis during serum-induced injury after amino Calpain Inhibitor II, ALLM mg starvation [72]. The first step of glutamine catabolism is its conversion
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The normal function of the
2022-01-07
The normal function of the FBPase enzyme is to catalyze the hydrolysis of F1,6BP to F6P. This activity is induced by diabetes and starvation and is increased in diabetic rats. The level of FBPase can be normalized by insulin, however, similar information is not available from diabetic patients. FBPa
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Chi square tests with significance set to
2022-01-07
Chi-square tests with significance set to p Results There were 4090 hip fracture patients included in the study. 2326 of these received enoxaparin, 929 received XaI, and 835 received warfarin. The mean CCI for each group was 3 (Table 2). There were some significant differences in demographics betw
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Dithiodipyridine also known as aldrithiol is a known zinc ej
2022-01-07
2,2′-Dithiodipyridine , also known as aldrithiol, is a known zinc ejector, targeting for instance the zinc finger in nucleocapsid protein of human immunodeficiency Necrostatin 1 type 1. inhibited G9a activity with IC = 0.65 µM and GLP with IC = 2.6 µM. We also tested disulfide cysteamine dihydrochl
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Introduction Hedgehog HH signaling regulates development cel
2022-01-07
Introduction Hedgehog (HH) signaling regulates development, cell proliferation, and tissue repair [1], [2], [3]. In mammals, HH signaling is activated by 3 ligands: Sonic hedgehog (SHH), Indian hedgehog (IHH), or Desert hedgehog; SHH is the most widely expressed in adult tissues [3]. The primary re
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br Materials and methods br Results We studied patients
2022-01-07
Materials and methods Results We studied 16 patients infected with HCV genotypes 1a and 1b, naïve for protease inhibitor-based therapy. All patients, chronically infected, were selected by the Hepatology Department for triple therapy. Most of them had severe liver fibrosis at the beginning of
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Approximately mammalian genes encoding family A or rhodopsin
2022-01-06
Approximately 250 mammalian genes encoding family A (or rhodopsin-like) GPCRs have been cloned (Lee et al., 2001a). As yet, the total number of cloned GPCRs reported in the literature including the secretin and metabotropic glutamate-like families of GPCRs falls short of the projected 616 GPCR-encod
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