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The gene structures of cGalR and
2021-12-06
The gene structures of cGalR2 and cGalR2-L were determined by in silico comparison with the chicken genomic DNA sequences retrieved from the Ensembl database. Both cGalR2 and cGalR2-L genes are composed of two coding exons, separated by single introns of 0.9kb (cGalR2) or 3kb (cGalR2-L) locating wit
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At this point it needs however to be mentioned
2021-12-06
At this point it needs, however, to be mentioned that most in vivo studies regarding the herein discussed nuclear receptors were performed in rodents, especially in mice. Due to the significant differences in metabolism in mice and humans, not all results are translatable between these species and h
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We have isolated various bioactive peptides acting by
2021-12-06
We have isolated various bioactive Blebbistatin acting by binding to the receptors of endogenous bioactive peptides such as opioid, bradykinin, neurotensin, and complements C3a and C5a etc. [24]. Rubimetide is the first example of an agonist peptide of the FPR2 of exogenous origin. Anxiolytic-like
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In general the FDP gene is involved in
2021-12-06
In general the FDP gene is involved in isoprenoid biosynthesis for normal growth and development of plant species while it is specifically involved in rubber biosynthesis (cis-1,4-polyisoprene units) in Hevea plant. When the HbFDP gene was over-expressed under the control of constitutive promoter in
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Although it is well documented
2021-12-06
Although it is well documented that FAAH substrates can elicit analgesic effects [for review see [47,48] and that systemic poly I:C administration induces mechanical allodynia in rats [14], to our knowledge this is the first study to demonstrate that enhancing FAAH substrate levels can modulate TLR3
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The even bigger surprise was the second feature
2021-12-06
The even bigger surprise was the second feature of both structures. Interestingly, binding of the MRG domain hardly altered the conformation of the SET domain compared with its apo state (An et al., 2011). What did change, however, is the conformation of the ASH1L auto-inhibitory loop (Figure 1). De
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The study by Pigna and
2021-12-06
The study by Pigna and collaborators provides an elegant demonstration why class IIa HDAC inhibition may not be suitable to protect the neuromuscular function in ALS, consistent with a recent study that showed only a transient protection of motor performance after treatment of the same ALS model wit
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The second class of proteins
2021-12-06
The second class of proteins necessary for maintaining SB 258719 hydrochloride synthesis dynamics is chromatin modifiers, which are considered ‘writers’ and ‘erasers’ and are responsible for modifications of histone N-terminal tails. These post-translational modifications can have direct or indirect
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To identify structurally novel autophagy inhibitors a medium
2021-12-06
To identify structurally novel autophagy inhibitors, a medium throughput screen of our in-house library of approximately 160,000 compounds was performed. In the screening assay, MCF7 JNJ 5207852 dihydrochloride stably transfected with eGFP-tagged light chain 3 (LC3), were employed, which can be dete
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In humans the effect of GnRH and
2021-12-06
In humans, the effect of GnRH and hCG on trophoblast invasion was found to be mediated through extracellular matrix remodeling by facilitating the activity of MMP2 and MMP9 [13], [18], [44]. Both 46619 are collagenases that degrade extracellular matrix. In canines, this has not yet been investigate
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The effects of these steroids namely the decrease in
2021-12-06
The effects of these steroids, namely the decrease in the peak and acceleration of desensitization could be observed in IGly activated by 100 μM glycine (concentration close to EC50). However, with an increase in glycine to 500 μM (a concentration close to saturating), the effect of steroids on the
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Na K ATPase adenosine triphosphate
2021-12-06
Na+/K+-ATPase, 3 methyladenine and astrocytic glutamate transporters act together to maintain sodium and potassium gradients and the proper activities of EAAT1 and EAAT2 (Rose et al., 2009; Sheean et al., 2013); nevertheless, in present study, Na+/K+-ATPase activity was shown to be increased as fro
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The dopamine substrate currents IDA IControl were determined
2021-12-06
The dopamine substrate currents (IDA – IControl) were determined at different holding potentials (IV curves) in transfected HT22 cells (Fig. 5A). The plot for HT22 cells transfected with DAT exhibited the typical behavior of dopamine transporter currents (Ingram et al., 2002; Sonders et al., 1997),
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br Materials and methods br Results br Discussion
2021-12-06
Materials and methods Results Discussion Here, we investigated the inhibitory effects and associated mechanisms of phloroglucinol on α-glucosidase. Our results showed that phloroglucinol reversibly inhibited α-glucosidase in a dose-dependent manner (Fig. 1), with the double-reciprocal plot
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br Conflict of interest br Acknowledgment M
2021-12-06
Conflict of interest Acknowledgment M.D.P. lab is supported by the EPFL and Swiss National Science Foundation (SNF grant No. 200020_157153). Introduction As amyloid-β peptide (Aβ) accumulation in the 1661010 starts in the very early stages of Alzheimer’s disease (AD) pathology (Bateman et
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