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br Materials and methods br
2021-10-07
Materials and methods Results Human adipocytes, differentiated from fibroblastic preadipocytes in culture, were incubated with IL-33 for either 3 or 24 h to examine acute and prolonged responses to the cytokine. Low, medium and high concentrations of IL-33 were employed. IL-33 had no significa
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The rat model was validated with another agonist
2021-10-07
The rat model was validated with another agonist of GPR109A, acipimox. Acipimox has been shown to induce vasodilatation in man, by a mechanism dependent on the release of vasodilator prostaglandins (Edlund et al., 1990, Pontiroli et al., 1992). Acipimox is a weaker agonist of the GPR109A receptor (L
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Acknowledgment br Main Text From birth to
2021-10-07
Acknowledgment Main Text From birth to adulthood, humans progressively acquire and maintain a complex microbial ecosystem at various body sites and cavities. Early on, these microorganisms establish a complex relationship with the host, resulting in the modulation of several biological function
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Percentage contribution to free glutamate
2021-10-06
Percentage contribution to free glutamate intake was also calculated at the food item level. A list of the top 30 foods for children and adults are presented separately in Table 2. The top 4 foods included in this list are watermelon, raw; tomato catsup; tomatoes, raw; and roll, white, soft. These a
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There are also data showing potential
2021-10-06
There are also data showing potential beneficial effects of SGLT2i on non-alcoholic fatty liver disease (NAFLD) [[14], [15], [16], [17]], a hepatic manifestation of the metabolic syndrome that has been linked to type 2 diabetes mellitus (T2DM) development and increased cardiovascular (CV) as well as
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Two pathways have emerged to explain the
2021-10-06
Two pathways have emerged to explain the beneficial metabolic effect of Roux-en-Y bypass [Fig. 3]. Firstly, the rapid delivery of nutrients to the distal small intestine and bowel might up-regulate secretion of a physiological stimulus that improves glucose homeostasis. As such, GLP-1 represents an
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Moving forward to series the energy minimized conformation o
2021-10-04
Moving forward to series , the energy minimized conformation of protoporphyrin ix within the binding pocket is quite interesting. The indole-based tail guides the TZD head for a highly-favored interaction with all residues of the H-bonding triad (). In addition, an extra bonding with H449 in the AF-
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We conclude that a combination of GD specific CAR T
2021-10-03
We conclude that a combination of GD2-specific CAR T cell therapy with pharmacological EZH2 inhibition deserves investigation as a new therapeutic strategy in EwS and potentially other cancers with heterogeneous GD2 expression, including osteosarcoma, various soft tissue sarcomas, melanoma, lung can
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The primary physiological role of the HO system
2021-10-03
The primary physiological role of the HO system is the protection of Biocytin from oxidative stress. These cytoprotective effects are attributable both to the degradation of the pro-oxidant heme and to the positive contribution of the metabolites produced during this degradation, namely CO, BV, and
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Other N substituted carboxamide oxy pyridine derivatives a h
2021-10-03
Other N-substituted-6-carboxamide-3-oxy-pyridine derivatives 52a, 52h, 52i, and 53h were synthesized using an alternative route. The Pd-catalyzed Heck aminocarbonylation of 44 or 45 with (PPh3)2PdCl2 catalyst in the presence of Et3N under CO atmosphere successfully provided various N-substituted-6-c
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In diseased blood vessels increased production of reactive o
2021-10-03
In diseased blood vessels, increased production of reactive oxygen species (ROS), such as peroxynitrite, superoxide, and hydrogen peroxide, have been found [[53], [54], [55]]. Peroxynitrite was suggested to alter the redox state of sGC [53] while hydrogen peroxide interfered with the action of NO bu
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In order to determine whether NF B could interact with
2021-10-02
In order to determine whether NF-κB could interact with GSTP1-1 promoter, we performed EMSA. One NF-κB like (−98κB) binding site was previously described in the GSTP1-1 promoter as a regulator element. However, few data about this site have been published and its role in the GSTP1-1 gene regulation
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GSTs have been originally named ligandins because of their c
2021-10-02
GSTs have been originally named ‘ligandins’ because of their capacity to bind large ligand molecules (of molecular weight >400 Da) (Oakley et al., 1999). At least three separate 5-Methyl-UTP receptor have been reported for xenobiotics within the H-site; only one is for CDNB (Ralat and Colman, 2004)
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Fig demonstrates placental amino acid transporter protein co
2021-10-02
Fig. 7 demonstrates placental amino KU-0063794 transporter protein concentrations. While no change in the placental SNAT2 is effected in response to a high-fat diet in wt, a trend toward a reduction was seen in glut3 mice in response to a high-fat vs. chow diet (Fig. 7A and B). A high-fat diet did
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br Methods br Results br Discussion Among
2021-10-02
Methods Results Discussion Among three main signaling pathways activated by bFGF, the MAPK pathway was found to be involved in the upregulation of GR levels. So far, there have been a few candidates that could connect activated ERK to the upregulation of GR. One likely candidate is the zinc
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