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br Fragment based drug discovery FBDD is
2021-07-31
Fragment-based drug discovery (FBDD) is a powerful method to discover drug leads and has been widely adopted in both academia and industry. FBDD can be used to explore chemical PS 341 space with libraries which are smaller in size, producing drug leads with high ligand-binding efficiency. It also
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Natural and synthetic glucocorticoids perform
2021-07-31
Natural and synthetic glucocorticoids perform their biological action in the organism through receptor-dependent mechanisms (e.g., by binding to the glucocorticoid receptors). It has been determined that glucocorticoid receptors cross-talk with other nuclear receptors, including AhR (Celander et al.
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Many investigators participated in the studies on the
2021-07-31
Many investigators participated in the studies on the regulation of the Parthenolide sale and experiments indicated that the process was conserved across many eukaryotic species including humans [127]. Because cancer cells exhibit dysregulated cell division along with the presence of abnormal chrom
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br Experimental methods br Results
2021-07-31
Experimental methods Results and discussion Conclusions Here we describe the first reported method for high-yield PHA-793887 of active and soluble mature CPG2 (in the absence of the leader peptide) and its individual catalytic and dimerization domains in E. coli. Such a method is of key im
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Magnetic interactions between metal ions
2021-07-31
Magnetic interactions between metal ions are usually described by superexchange via intermediate ligands. Although the general principles of the superexchange mechanism are essentially the same for d and f ions, calculations of exchange parameters for lanthanides are more difficult than for transiti
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Synthetic peptides have proven highly valuable in
2021-07-31
Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to synthetic collagen-like peptides. First, the thermal stability of
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Many processes can lead to
2021-07-31
Many processes can lead to changes in soil P pools over time. Plant-available P (when measured as DGT P) decreased over time for the INORG-P treatment (Fig. 1a). Orthophosphate can be stabilised with cations such as calcium to produce insoluble phosphates, reducing plant-available P (Bünemann et al.
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br Particle swarm optimization for
2021-07-31
Particle swarm optimization for NLBP Computational tests Conclusions Acknowledgements This work was supported by the State Key Development Program for Basic Research of China (No. 2009CB421104) and the National Natural Science Foundation of China (Nos. 50809004 & 41071323). Main Text
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br Experimental br Results and discussion On the basis
2021-07-30
Experimental Results and discussion On the basis of the information obtained from the studies on RHA/TiO2 nanocomposites, it liothyronine sodium is expected that this reagent can be used as a catalyst for the promotion of the organic reactions. So this reagent was used in the promotion of the
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On the opposite side sPLA
2021-07-30
On the opposite side, sPLA2-X has also been implicated in the pathology of cancer [167,168]. Human sPLA2-X induces lipid droplet formation in Ras-driven MDA-MB-231 triple-negative breast cancer Bindarit and promotes their survival during nutrient stress. It acts through the products of its enzymati
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The glycolytic pathway is a catabolic route that ends
2021-07-30
The glycolytic pathway is a catabolic route that ends with the synthesis of pyruvate (Pyr). In Arabidopsis embryos, the conversion of phosphoenolpyruvate (PEP) to Pyr, catalyzed by pyruvate kinase (PK), is mainly located in the plastids [10], [11]. The preceding reaction is catalyzed by enolase (ENO
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Materials and methods br Results Assay of botulinum toxin
2021-07-30
Materials and methods Results Assay of botulinum toxin activity is critical for the risk-assessment, diagnosis, and treatment of botulism cases. The frequently encountered active forms of the toxin are; L chain (inside intoxicated neuronal cells), BoNT (in the blood stream of a botulism patient,
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Pyruvate dehydrogenase multienzyme complex PDHc catalyzes th
2021-07-30
Pyruvate dehydrogenase multienzyme complex (PDHc) catalyzes the oxidative decarboxylation of pyruvate, and subsequently acetylates coenzyme A (CoA) to acetyl-CoA during the tricarboxylic BRD 7389 metabolic pathway using thiamine diphosphate (ThDP) and Mg2+ as cofactors. PDHc poses a key role in cya
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br Are incretins the only mediators of
2021-07-30
Are incretins the only mediators of the anti-hyperglycaemic effects of DPP-4 inhibitors? Even though both GLP-1 and GIP were identified as substrates for DPP-4 early on [17], [19], [20], [22], and DPP-4 inhibition in vivo raises levels of the intact endogenous forms of both of them [43], [44], fr
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br Materials and methods br Results
2021-07-30
Materials and methods Results Discussion Structural analysis of dnmt3 sequences of different ploidy fish cloned in this study showed high similarities to zebrafish sequences, which also contained a unique N-terminal motif and a calponin homology (CH) domain, a conserved proline-tryptophan-t
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