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Lavallee et al reported that PREG could be esterified by
2021-06-11
Lavallee et al. [30] reported that PREG could be esterified by lecithin:cholesterol acyltransferase (LCAT). LCAT uses cholesterol and phosphatidyl choline present in the newly formed high-density lipoprotein (HDL) as substrates and convert them into cholesteryl esters and lysophosphatidyl choline. T
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WAY 208466 dihydrochloride Our study revealed elevated basal
2021-06-11
Our study revealed elevated basal Akt phosphorylation in diet-induced obesity, the effect of which was reversed by ETAKO. Activation of Akt promotes cardiac hypertrophy via a number of cellular mechanisms including activation of its downstream targets such as mTOR and GSK3β [45, 46]. Short-term acti
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Senexin A br Results and discussion br Conclusion
2021-06-11
Results and discussion Conclusion Recent studies showed that EGFR signaling is involved in inflammatory response in several inflammatory conditions. The normal inflammatory macrophage Senexin A show EGFR-dependent production of inflammatory mediators. Nevertheless, the development of EGFR inh
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br Oxysterols as Key Players
2021-06-11
Oxysterols as Key Players in Metabolic Syndrome? Obesity and sedentary lifestyle are on the rise and pose serious threats to people's health and wellbeing. Obesity is often associated with other pathologies and is one of the criteria included in the definition of metabolic syndrome (MetS) (see Gl
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Ubiquitination is a covalent attachment of
2021-06-11
Ubiquitination is a covalent attachment of 76 amino 5104 ubiquitin molecules to target proteins, either as single moieties (mono-ubiquitination) or as poly-ubiquitin chains of different structures, formed through isopeptide bonds between specific lysines of one ubiquitin residue (for example K48, K
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Concerning family A GPCRs although it has
2021-06-11
Concerning family A GPCRs, although it has been described that several receptors are able to operate as monomers (Arcemisbéhère et al., 2010; Bayburt et al., 2011; Chabre & le Maire, 2005; Ernst, Gramse, Kolbe, Hofmann, & Heck, 2007; Hanson et al., 2007; Kuszak et al., 2009; Whorton et al., 2007), e
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There are numerous resources clinicians
2021-06-10
There are numerous resources clinicians may use to gather information on the strength of evidence related to pharmacogenetic-based dosing and treatment decisions, as well as specific dosing guidelines, some of which are summarized in this review. These include resources from CPIC, which provides pee
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In the case of ionic liquids the association
2021-06-10
In the case of ionic liquids, the association scheme should be determined and considered for calculations. H. Soltani Panah (2017) suggested the 2B scheme for the imidazolium-based ionic liquids. His speculation has been used in this study for the modeling [22]. Considering 2B association scheme, th
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Early tubular differentiation in WT lacks lumen
2021-06-10
Early tubular differentiation in WT lacks lumen formation and, therefore, sometimes can be confused with rosettes of ES/PNET or neuroblastoma. However, tubular structure usually has ABT 702 dihydrochloride neatly aligned to form a single layer around the future lumen, whereas neuroblastic rosettes
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Amrubicin br Conclusions br Declaration of interest br Ackno
2021-06-10
Conclusions Declaration of interest Acknowledgements Introduction Uncorrected obesity has been a major health problem and the prevalence of obesity is fast rising reaching an epidemic proportion [[1], [2], [3]]. Ample of clinical and experimental evidence has suggested that obesity leads
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Cdk1/2 Inhibitor III br Materials and methods br
2021-06-09
Materials and methods Results Discussion The present study shows that 1) overexpression of wild-type or mutant α-SYN interferes with forskolin-induced DBH up-regulation, 2) α-SYN enters into the nucleus and is able to bind to CRE region, compete for CREB, and attenuate CRE-mediated transcri
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br Conflicts of interest br Introduction G
2021-06-09
Conflicts of interest Introduction G protein-coupled receptors (GPCRs), form the largest human membrane protein family, with 800 members overall. Many druggable targets for treatment of common diseases involve GPCRs that mediate therapeutic effects of 34% of all marketed drugs (Hauser, Attwood
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In addition to through direct regulation
2021-06-09
In addition to through direct regulation of cell differentiation, DDR2 may raise the abundance of myofibroblast subsets through advancing the recruitment of its precursor cells. One such evidence is that DDR2 can regulate lung fibroblast proliferation and migration. Another possibility rests on the
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GSK2606414 br Results br Discussion The most relevant overal
2021-06-09
Results Discussion The most relevant overall finding was that DDR1 is present in myelin and is probably synthesized by oligodendrocytes. This result was supported by three different approaches. First, we detected presence of DDR1 mRNA in myelin by ISH. Second, the pattern of DDR1 immunostainin
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The HPV E proteins are acidic
2021-06-09
The HPV E7 proteins are acidic oncoproteins of approximately 98–103 CHIR-98014 that contain 3 domains: the conserved region (CR) 1, CR2, and the carboxyl terminal (C-terminal) domain. The CR1 domain is necessary for cellular transformation and RB degradation in mucosal high risk HPVs. The CR2 domai
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