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Sixty eight male Sprague Dawley rats were
2021-06-02
Sixty-eight male Sprague–Dawley rats were acquired from the University of South Dakota Laboratory Animal Services (Vermillion, SD, USA) and housed in pairs at 22°C (60% relative humidity) on reverse 12h light/dark Cathepsin S inhibitor (dark cycle started at 10:00a.m.) with food and water freely ac
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Animal studies investigating the role of
2021-06-02
Animal studies investigating the role of D1 dopamine receptors in the PFC have focused on delayed response tasks, which require online maintenance of a previously presented stimulus. Striatal dopamine is thought to be important for flexibility and updating goal representations when new information i
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Organ fibrosis is thought to be initiated by repeated or
2021-06-02
Organ fibrosis is thought to be initiated by repeated or chronic epithelial injury. The current belief is that damaged epithelial Nucleozin induce an aberrant and unresolved wound repair process by activating fibroblasts via various profibrotic cues. Upon injury, epithelial cells activate the profi
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Moreover as shown in Fig f while
2021-06-02
Moreover, as shown in Fig. 5f, while the knockdown of SMURF2 in wild-type Phosphatase Inhibitor Cocktail 2 (100X in ddH2O) has no significant effect on HSP27, in CK2α/α′(−/−) cells it leads to an increase of HSP27 level. These results suggest that SMURF2 affects HSP27 protein stability only when ov
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Therefore the relationship between ChEs activity and
2021-06-02
Therefore, the relationship between ChEs activity and polymorphisms in POT1, TERF1, TERT genes were explored in order to screen susceptible biomarkers in this study. Materials and methods Results Discussion However, genetic toxicity induced by OPs has not been fully investigated so far. Ca
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Recently pharmacological studies have revealed
2021-06-02
Recently, pharmacological studies have revealed that natural compounds achieve increasing attention due to its high therapeutic effectiveness and low adverse effect, compared with the chemically synthesized compounds. Emodin is a kind of natural anthraquinone derivative enriched in traditional Chine
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br Materials and methods br Results br Discussion The oestro
2021-06-02
Materials and methods Results Discussion The oestrogen agonist properties and androgen antagonist activities of parabens have been well documented by a variety of in vitro and in vivo assay systems over the past decade (Chen et al., 2007, Darbre and Harvey, 2008, Golden et al., 2005). To th
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Roflumilast Among the down regulated genes were several of i
2021-06-02
Among the down-regulated genes were several of interest. Coronin2a (Coro2a), a component of the nuclear receptor co-repressor complexes, contributes to de-repression of inflammatory response genes (Huang et al., 2011). Mill1, an MHC family member expressed in hair follicles, represses wound healing
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Only a few studies have examined
2021-06-02
Only a few studies have examined the effect of prostanoids on cardiac fibroblasts. Therefore, this study examines the effect of PGE2 on cardiac fibroblast proliferation and tests the hypothesis that PGE2 causes cardiac fibroblast proliferation via alterations of Isochlorogenic acid A regulatory mol
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In conclusion we designed novel E
2021-06-02
In conclusion, we designed novel E1 inhibitors based on the three-dimensional structure of E1 in complex with ubiquitin. Following an enzymatic assay evaluating synthetic compounds , , and , we identified compound as a novel E1 inhibitor. Comparing the inhibitory activity of compound with and ,
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AP1903 Another important new result that has expanded the ra
2021-06-02
Another important new result that has expanded the range of functions of iPLA2-VIA in physiology and pathophysiology is its implication in macrophage polarization under stimulation conditions. Ashley et al. [129] described in peritoneal macrophages from Pla2g6−/− mice that the absence of iPLA2-VIA f
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Introduction The annual global market of industrial enzymes
2021-06-02
Introduction The annual global market of industrial 3CAI receptor is reported to be billions of USD [1], [2], [3], [4], [5], [6], [7], and impacts commercial sectors that include energy, animal feed, household products, food processing and pharmaceuticals [1], [2], [5], [6]. Enzymatic processing is
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We propose the following model for how
2021-06-01
We propose the following model for how B cell-guiding EBI2 ligand gradients are established in lymphoid tissues. CH25H and CYP7B1 are needed in radiation-resistant stromal cells, are abundantly expressed and active in CXCL13+ and CCL21+ FRCs, but not lymphocytes, and are poorly expressed in the inne
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br Future perspectives Understanding how peptides are degrad
2021-06-01
Future perspectives Understanding how peptides are degraded, particularly those which may be therapeutically useful, such as GLP-1, has proved to be invaluable in providing a rationale for the development of a novel class of therapeutic agents. However, while DPP-4 plays an important role in the
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Impaired dopaminergic systems associated with MA have been w
2021-06-01
Impaired dopaminergic systems associated with MA have been well-documented (Walsh and Wagner, 1992, Kim et al., 1999, Nakajima et al., 2004, Shin et al., 2012, Shin et al., 2017b, Dang et al., 2016, Dang et al., 2017b). Previous reports have suggested that early MA use may be linked to higher risk
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