• Which is the preferred dimer configuration the one correspon

  2021-09-14

  

  Which is the preferred dimer configuration, the one corresponding to the active state or the one corresponding to the desensitized state? Umbrella sampling simulations of a pair of GluA2 LBDs, using distances at the top (proximal to the ATD) and the bottom (proximal to the TMD), indicate that the de

• The lactam compounds including ceftriaxone CEF have shown to

  2021-09-13

  

  The β-lactam compounds, including ceftriaxone (CEF), have shown to attenuate drug-seeking in several drugs of abuse including methamphetamine [31], cocaine [32,33], nicotine [34] and morphine [35]. Moreover, in our laboratory, we have shown that CEF can reduce chronic alcohol drinking via upregulati

• Another interesting approach is to use partial agonists as s

  2021-09-13

  

  Another interesting approach is to use partial agonists as starting point to develop specific antagonists like done in earlier decades [64], [65]. Possible indications for an attenuation of the NO/sGC signalling pathway might be specific neuronal disorders: an involvement in the aetiology of migrain

• Lactate LA the end product of aerobic glycolysis

  2021-09-13

  

  Lactate (LA), the end product of aerobic glycolysis, has been long neglected and seen as a byproduct until recently the findings for its important role in global gene transcription, cancer progression, functional polarisation of immune moxalactam and the sustenance of stem cells [[7], [8], [9]]. Lac

• SCH 23390 hydrochloride The hypothesis that genes involved i

  2021-09-13

  

  The hypothesis that genes involved in type 2 diabetes evolved under changing selective pressures and may carry the signature of natural selection motivated us to describe patterns of sequence variation at CAPN10 and GPR35 in human populations. An initial population genetics study reported an unusual

• br Competing interests br Introduction An

  2021-09-13

  

  Competing interests Introduction An effective vaccine against the Human immunodeficiency virus (HIV) is still to be created, even though many strategies have already been tried [1]. Antibodies against a vaccine antigen must be either neutralizing or inducing cellular cytotoxicity [1]. It is kn

• New follicular wave emergence is associated

  2021-09-13

  

  New follicular wave emergence is associated closely with the stage of the estrous Kenpaullone (Sirois and Fortune, 1988). As indicated by results from the present experiment, cows that had regression of the largest follicle on Day 0 of treatment onset had follicle wave characteristics that were con

• Accordingly a bioassay guided approach was been used

  2021-09-13

  

  Accordingly, a bioassay-guided approach was been used to study the bioactive compounds in VAS contribute to the α-glucosidase inhibitory and antioxidant activity. The 95% ethanol extraction of VAS was successively partitioned with petroleum ether, ethyl acetate and n-butanol. Ethyl acetate fraction

• However it is unclear whether

  2021-09-13

  

  However, it is unclear whether the parent and transition metal substitution in Keggin-type phosphomolybdic Ro 08-2750 will reveal the best effects on α-glucosidase. Therefore, the Keggin-type H3PMo12O40 (abbreviated as PMo12) and three transition metal-substituted POMs (Na4PMo11VO40, Na6PMo11FeO40

• Although encoded by a single gene GR displays

  2021-09-13

  

  Although encoded by a single gene, GR displays considerable heterogeneity through the combined effects of alternative mRNA splicing, alternative translation initiation, and complex post-translational modification. Differential expression of the various GR isoforms may contribute to tissue-specific f

• Further we examined the degradation of

  2021-09-13

  

  Further, we examined the degradation of Cx43. Autophagy and the proteasome system have previously been implicated in Cx43 degradation (Falk et al., 2014). DEX inhibited communication between ion channel by promoting the degradation of Cx43 through autophagy in osteocytes (Gao et al., 2016). In our

• br Introduction Alzheimer s disease AD affects ca million pe

  2021-09-13

  

  Introduction Alzheimer's disease (AD) affects ca. 46 million people worldwide [1] and it is expected that the number will double or triple by 2030 or 2050, respectively, while no significant progress has been made in research for early diagnosis and new efficient therapies. Currently available me

• Furthermore our results are the first to demonstrate that

  2021-09-13

  

  Furthermore, our results are the first to demonstrate that the stimulating effect of GALP on AVP release in rats is independent of galanin receptors. The same stimulatory GALP influence on AVP secretion has been also observed in the presence of galantide, an antagonist of Gal receptors in the incuba

• In regards to animals several studies have reported the

  2021-09-13

  

  In regards to animals, several studies have reported the peroxisomal localization of FPS (Krisans et al., 1994, Olivier et al., 2000, Kovacs et al., 2007). Transfections of mammalian cells with the rat short FPS isoform followed by immunodetection localized the enzyme to the peroxisome (Olivier et a

• The H R antagonist cimetidine Tagamet

  2021-09-13

  

  The H2R antagonist cimetidine (Tagamet™) became the first billion-dollar drug in the 1980s for the treatment of peptic ulcer disease. Other H2R antagonists include ranitidine, famotidine, nizatidine, and zolantidine, the latter showing good BBB penetration with a steady-state brain/blood ratio of 1.

16042 records 569/1070 page Previous Next First page 上5页 566567568569570 下5页 Last page