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PMX 205 br Introduction A variety of means including UV
2021-03-04
Introduction A variety of means, including UV irradiation, dNTP depletion, and oncogene activation at precancerous lesions, induce replication stress, which causes replication errors if left undealt with (Hills and Diffley, 2014, Zeman and Cimprich, 2014). Eukaryotic cells have developed the DNA
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The Nile tilapia Oreochromis niloticus is
2021-03-04
The Nile tilapia (Oreochromis niloticus) is an important farmed fish with an XX/XY sex-determining system. The availability of the whole genome sequence of tilapia and tissue transcriptomes (Brawand et al., 2014), together with its gonadal transcriptomes at different developmental stages (Tao et al.
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Collagen X is a homotrimeric molecule of three X chains
2021-03-04
Collagen X is a homotrimeric molecule of three α1(X) chains (Mr 59 kDa) comprising a 45 kDa triple-helical domain flanked by an N-terminal (NC2) and a larger C-terminal (NC1) non-collagenous domains (Shen, 2005). In the hypertrophic ECM, collagen X most likely forms an extended hexagonal network, as
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The CysLT receptor antagonist BayCysLT RA significantly
2021-03-04
The CysLT2 receptor antagonist BayCysLT2RA significantly suppressed multiple antigen challenge-induced infiltration of eosinophils and mononuclear AZD2932 into the lung, indicating that CysLT2 receptor activation is involved in leukocyte migration. In contrast to the present finding, Barret et al.
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Introduction Cyclin dependent kinases CDKs are a family
2021-03-04
Introduction Cyclin dependent kinases (CDKs) are a family of proline-directed serine/threonine kinases with roles in regulation of crucial cellular processes such as Pefloxacin and transcription [1]. One of the unifying features of this family is its dependence on association with cyclins/cyclin-l
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DDX belongs to the DEAD box
2021-03-03
DDX3 belongs to the DEAD-box family of proteins, ATP-dependent RNA helicases characterized by the presence of a highly conserved helicase core domain [13]. This catalytic core is composed of two RecA-like domains containing motifs involved in ATP binding/hydrolysis, RNA binding and helicase activity
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PCI32765 To date little is known
2021-03-03
To date, little is known about mode of action or the underlying genetic basis of DEET repellency for human-biting ticks. To begin to unveil these mechanisms, we carried out behavioral assays to confirm the effectiveness of DEET as a deterrent for D. variabilis. RNA sequencing was then used to build
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5-Iodotubercidin So what can we glean from this illuminative
2021-03-03
So what can we glean from this illuminative foray into how Chk1 and MK2 participate in checkpoint control? First and foremost, this work reveals that 5-Iodotubercidin deficient in the tumor suppressor p53 contain two spatially distinct G2/M phase checkpoint control kinase networks. This provides co
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br Materials and methods br Results br
2021-03-03
Materials and methods Results Discussion In this study, we confirmed the activation of Akt by udenafil in 3T3-L1 cells. To elucidate the underlying mechanism of udenafil, we focused on the mitochondria. Our findings demonstrated that udenafil improved mitochondrial function and expression o
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Of all the residues of plants the ash obtained from
2021-03-03
Of all the residues of plants, the ash obtained from the incineration of RH has highest amount of silica content [7]. The rice crop normally ingest orthosilicic nucleoside analogs in large quantity from ground water and this acid is further polymerized in the husk, ultimately contribute to amorphous
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In this report we describe studies of the effects of
2021-03-03
In this report we describe studies of the effects of peroxisome proliferator-activated receptor γ (PPARγ) and acyl-CoA synthetase (ACSL1) on palmitate-induced ER stress in the human cardiomyocyte-like cell line AC16 [22], which was derived from adult ventricular heart tissue. PPARγ is a nuclear rece
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br Conclusion The results of the current study show that
2021-03-03
Conclusion The results of the current study show that boldness is associated with higher gene expression of drd2a, drd2b and oprd1b in zebrafish males. The results are correlational and additional experiments are needed to clarify the causal role of these receptors in zebrafish behavior. Confl
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DGK is classified into the type
2021-03-03
DGKη is classified into the type II DGK subfamily [12], [13], [14], [15]. As described above, DGKη has the splice variants η1 and η2 [10]. DGKs η1 and η2 possess in common a pleckstrin homology domain at the N-terminus and a catalytic domain that is divided into two subdomains (catalytic subdomain-a
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br Acknowledgments The authors thank Elisabete Lepera and
2021-03-03
Acknowledgments The authors thank Elisabete Lepera and Rosana Silva for technical support. The study was supported by FAPESP, CNPq and PADC/FCF-UNESP. T.T. Miguel was the recipient of a FAPESP (Proc. 05/05171-1) and R.L. Nunes-de-Souza of a CNPq (Proc. 303580/2009-7) fellowship. Introduction
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In this review we first introduce the in vivo
2021-03-03
In this review, we first introduce the in vivo metabolism profile of VD3, and the mediation of Cyp3a gene transcription by PXR and CAR in humans, mice and rats. We then focus on the species-specific VDR-dependent regulation of human (CYP3A4, CYP3A5 and CYP3A7), mouse (mainly CYP3A11 and CYP3A13), an
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