• Introduction Cyclin dependent kinases CDKs are a family

  2021-03-04

  

  Introduction Cyclin dependent kinases (CDKs) are a family of proline-directed serine/threonine kinases with roles in regulation of crucial cellular processes such as Pefloxacin and transcription [1]. One of the unifying features of this family is its dependence on association with cyclins/cyclin-l

• DDX belongs to the DEAD box

  2021-03-03

  

  DDX3 belongs to the DEAD-box family of proteins, ATP-dependent RNA helicases characterized by the presence of a highly conserved helicase core domain [13]. This catalytic core is composed of two RecA-like domains containing motifs involved in ATP binding/hydrolysis, RNA binding and helicase activity

• PCI32765 To date little is known

  2021-03-03

  

  To date, little is known about mode of action or the underlying genetic basis of DEET repellency for human-biting ticks. To begin to unveil these mechanisms, we carried out behavioral assays to confirm the effectiveness of DEET as a deterrent for D. variabilis. RNA sequencing was then used to build

• 5-Iodotubercidin So what can we glean from this illuminative

  2021-03-03

  

  So what can we glean from this illuminative foray into how Chk1 and MK2 participate in checkpoint control? First and foremost, this work reveals that 5-Iodotubercidin deficient in the tumor suppressor p53 contain two spatially distinct G2/M phase checkpoint control kinase networks. This provides co

• br Materials and methods br Results br

  2021-03-03

  

  Materials and methods Results Discussion In this study, we confirmed the activation of Akt by udenafil in 3T3-L1 cells. To elucidate the underlying mechanism of udenafil, we focused on the mitochondria. Our findings demonstrated that udenafil improved mitochondrial function and expression o

• Of all the residues of plants the ash obtained from

  2021-03-03

  

  Of all the residues of plants, the ash obtained from the incineration of RH has highest amount of silica content [7]. The rice crop normally ingest orthosilicic nucleoside analogs in large quantity from ground water and this acid is further polymerized in the husk, ultimately contribute to amorphous

• In this report we describe studies of the effects of

  2021-03-03

  

  In this report we describe studies of the effects of peroxisome proliferator-activated receptor γ (PPARγ) and acyl-CoA synthetase (ACSL1) on palmitate-induced ER stress in the human cardiomyocyte-like cell line AC16 [22], which was derived from adult ventricular heart tissue. PPARγ is a nuclear rece

• br Conclusion The results of the current study show that

  2021-03-03

  

  Conclusion The results of the current study show that boldness is associated with higher gene expression of drd2a, drd2b and oprd1b in zebrafish males. The results are correlational and additional experiments are needed to clarify the causal role of these receptors in zebrafish behavior. Confl

• DGK is classified into the type

  2021-03-03

  

  DGKη is classified into the type II DGK subfamily [12], [13], [14], [15]. As described above, DGKη has the splice variants η1 and η2 [10]. DGKs η1 and η2 possess in common a pleckstrin homology domain at the N-terminus and a catalytic domain that is divided into two subdomains (catalytic subdomain-a

• br Acknowledgments The authors thank Elisabete Lepera and

  2021-03-03

  

  Acknowledgments The authors thank Elisabete Lepera and Rosana Silva for technical support. The study was supported by FAPESP, CNPq and PADC/FCF-UNESP. T.T. Miguel was the recipient of a FAPESP (Proc. 05/05171-1) and R.L. Nunes-de-Souza of a CNPq (Proc. 303580/2009-7) fellowship. Introduction

• In this review we first introduce the in vivo

  2021-03-03

  

  In this review, we first introduce the in vivo metabolism profile of VD3, and the mediation of Cyp3a gene transcription by PXR and CAR in humans, mice and rats. We then focus on the species-specific VDR-dependent regulation of human (CYP3A4, CYP3A5 and CYP3A7), mouse (mainly CYP3A11 and CYP3A13), an

• Based on the ability of CRF

  2021-03-03

  

  Based on the ability of CRF to modulate nociception, we hypothesized that stress leads to hyperalgesia by the activation of CRF1 and/or CRF2 receptors in the spinal cord. We tested this hypothesis using an acute forced swim as a widely used and easily reproducible stressor and grip force as a measur

• In the last and the most challenging part

  2021-03-03

  

  In the last and the most challenging part, three mixtures were selected to evaluate the reliability of the presented correlation and the CPA model. For Athabasca bitumen, Amani et al. [25] measured the experimental data at very high temperatures compared to the thermal recovery range up to 644 K (ne

• Among the different factors that modulate Schwann cell

  2021-03-02

  

  Among the different factors that modulate Schwann cell biology, several studies pointed out the role played by neuroactive steroids, in particular progesterone (P4) and its derivatives dihydroprogesterone (DHP) and allopregnanolone (ALLO). Schwann rosavin are steroidogenic, possessing the entire enz

• Our study revealed elevated basal

  2021-03-02

  

  Our study revealed elevated basal Akt phosphorylation in diet-induced obesity, the effect of which was reversed by ETAKO. Activation of Akt promotes cardiac hypertrophy via a number of cellular mechanisms including activation of its downstream targets such as mTOR and GSK3β [45, 46]. Short-term acti

15884 records 670/1059 page Previous Next First page 上5页 666667668669670 下5页 Last page