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To assess the involvement of the hydrocarbon
2020-07-30
To assess the involvement of the hydrocarbon chain of C75-CoA positioning in the acyl group binding pocket, we carried out C75-CoA inhibitory experiments with the new mutated protein, CrAT D356A/M564G. This protein has a deep SMER 3 pocket for the binding of long-chain instead of short-chain acyl-Co
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DNA methylation is an important mechanism
2020-07-30
DNA methylation is an important mechanism regulating gene expression, and it is required for normal mammalian development.26, 27, 28 Alteration in DNA methylation is a hallmark of cancer10, 29, 30 and may be observed as a loss of global methylation or as a gain of methylation of selected CpG islands
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Transcriptional mapping of the SYNE gene focusing on the CPG
2020-07-30
Transcriptional mapping of the SYNE1 gene, focusing on the CPG2 region, is a first step towards clarifying which of its transcripts and protein products are likely to play a role in BD. Identification of a full-length CPG2 transcript expressed in human brain encoding a protein that is functionally c
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AG-120 mg br Introduction Phase behavior models for mixtures
2020-07-30
Introduction Phase behavior models for mixtures of bitumens (or heavy oils) and n-alkanes are required for the simulation of solvent-assisted in situ heavy oil recovery processes, solvent based oil sand extraction processes, and solvent deasphalting processes [1,2]. These mixtures can form multip
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The small molecule d mannuronic acid M
2020-07-30
The small molecule β-d-mannuronic WIN 18446 receptor (M2000), patented (DE-102016113018.4), has been tested as an anti-inflammatory and a novel immunosuppressive agent in various experimental models such as animal models of immune complex glomerulonephritis, nephrotic syndrome, multiple sclerosis a
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Mitigation Strategies Enforcement Most relevant outcomes com
2020-07-30
Mitigation Strategies Enforcement Most relevant outcomes coming from TMS modeling are leveraged to propose possible ways useful to enhance the final cluster THR. In this work, mitigation strategies are proposed to address both software and hardware failures. Possible identified solutions were: (i) i
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These results are consistent with current models of CMV pers
2020-07-30
These results are consistent with current models of CMV persistence and reactivation. In immunocompetent individuals, CMV elicits a vigorous innate and adaptive immune response. Adaptive responses include induction of strongly neutralising humoral responses against GSK1324726A required for systemic
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Their action is based on esterification of a
2020-07-30
Their action is based on esterification of a serine hydroxyl group found in the active center of the AChE [7]. This results in modification of the AChE, leaving it without its biological role and effectively preventing the enzyme from breaking down the Cyclo molecule. Accumulation of acetylcholine
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The promoter of human DNA PKcs has not been
2020-07-29
The promoter of human DNA-PKcs has not been fully analyzed. Although the presence of a GC-rich region was reported, the direct analysis of DNA-PKcs promoter activity has not been performed [19], [38]. Our promoter analysis revealed that various factors and promoter areas are involved in its transcri
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br Experimental Melting points oC were determined by
2020-07-29
Experimental Melting points (oC) were determined by open capillary tube method using (Bio Cote SMP 10) apparatus and they are uncorrected. Microanalyses were performed using FLASH 2000 CHNS/O analyzer, Thermo Scientific at the Regional Center for Mycology and Biotechnology (RCMB), Al-Azhar Univer
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DDR is characterized by an N terminal discoidin domain and
2020-07-29
DDR2 is characterized by an N-terminal discoidin domain and a C-terminal kinase domain [7]. Characteristics of DDR1, which is a homologue of DDR2, have been extensively investigated in terms of L002 level in cancer tissues and biological functions in normal and cancer cell conditions, but character
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br Patients and Methods br Results br
2020-07-29
Patients and Methods Results Discussion Atherosclerosis is one of the most common risk factors for IS. The process of atherosclerosis is closely related to lipid metabolism. According to guidelines from the American Heart Association/American Stroke Association, lipid-lowering therapy is a
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Udenafil Zydena Dong A Seoul Korea a recently developed sele
2020-07-29
Udenafil (Zydena®; Dong-A, Seoul, Korea), a recently developed selective PDE-5I, showed promising pharmacokinetic characteristics for use in a once-daily strategy with a peak plasma concentration at 0.8–1.3 hours, which then declines monoexponentially with a kn to nm (T1/2) ranging from 9.9 to 12.1
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maprotiline Recently a method for in vivo photoactivation of
2020-07-28
Recently, a method for in vivo photoactivation of maprotiline expressing PA-GFP in precise microanatomical compartments was described (Victora et al., 2010), which makes it possible to optically mark Tfh cells and track them 20 hr later (Shulman et al., 2013). Unexpectedly, it was reported that Tfh
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Converging evidence indicated a possible connection between
2020-07-28
Converging evidence indicated a possible connection between hyperthermic and neurotoxic responses of AMPHs [[52], [53], [54]]. Earlier reports suggested that MA-induced hyperthermia may be important for striatal dopamine depletion [52], formation of dopamine quinones [55], and thereby production of
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