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Although PD is traditionally viewed as
2020-06-09
Although PD is traditionally viewed as a motor disorder, evidence from numerous epidemiologic (Shiba et al., 2000) as well as case–control studies (Richard, 2005) suggest the occurrence of non-motor symptoms including hyposmia/anosmia, gastrointestinal disturbances, sleep abnormalities, autonomic dy
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br Materials and methods br Results br Discussion Intra BNST
2020-06-09
Materials and methods Results Discussion Intra-BNST injections of NOC-9 (at all doses) were able to produce freezing and anxiogenic-like effects. Freezing was observed immediately after the NO donor injection and lasted about 2–3min (data not shown). When exposed to the EPM 5min after intra
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mi2 mg br Acknowledgments We thank the Lapaha Community and
2020-06-09
Acknowledgments We thank the Lapaha Community and Nobles (His Serene Highness Prince Kalaniuvalu Fotofili, Her Serene Highness Princess Marcella Taumoepeau Tupou Kalaniuvalu Fotofili and Her Royal Highness Mele Siu\'ilikutapu Kalaniuvalu Fotofili) and the Ministry of Internal Affairs (Government
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br Study br Study meta
2020-06-09
Study 1 Study 2: meta-analyses Discussion Ten studies have examined the associations of 5-HTTLPR and COMT Val158Met with alexithymia. However, the findings were mixed. In this study, we found that neither the 5-HTTLPR nor COMT Val158Met is associated with alexithymia. The previous findings
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br Materials and methods br Results
2020-06-09
Materials and methods Results Discussion Fluoride has multiple effects that contribute to caries prevention. S. mutans is 20- to 40-fold more sensitive to NaF than Lactobacillus casei and seven-fold more sensitive than some species of Actinomyces[10]. There are some specific metabolic effec
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br Transparency document br Acknowledgments
2020-06-09
Transparency document Acknowledgments This study was funded by ICMR, Govt. of India. Alisha Dhiman acknowledges UGC-DSKPDF, India for post-doctoral fellowship and Monisha Gopalani acknowledges CSIR, India for Senior Research Fellowship. AIRF, JNU is acknowledged for TEM, confocal microscopy an
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cyp450 inducers To our knowledge this is the first
2020-06-09
To our knowledge, this is the first report of an oncocytoma expressing alpha-enolase or causing autoimmune retinopathy and optic neuropathy. Although generally considered benign, oncocytomas have rarely been associated with paraneoplastic syndromes, including tumor-induced hypertension, erythrocytos
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br Methods Ventricular cardiomyocytes from adult male Wistar
2020-06-09
Methods Ventricular cardiomyocytes from adult male Wistar rats were isolated using a standard enzymatic digestion [11]. Cells were incubated at 37°C for 4 to 6h with Tyrode solution (in mM: 140 NaCl, 4 KCl, 1.1 MgCl2, 10 HEPES, 10 glucose, 1.8 CaCl2; pH7.4, with NaOH) supplemented or not with 10μ
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For the current studies we used
2020-06-09
For the current studies, we used the selective Epac agonist 8CPT-AM to directly activate the proteins. We chose this pharmacological approach since it allows a direct activation of Epacs rather than using receptor agonists such as PGE2 which could introduce confounding variables. One potential conce
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Immature and mature B cells
2020-06-09
Immature and mature Granzyme B Inhibitor Z-AAD-CH2Cl adapt differently to signal transduction via BCR [2]. This functional dichotomy is also regulated by noncytokine substances in the surroundings of mature and immature B lymphocytes, such as the prostanoid family of lipid mediators including PGD2,
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br Materials and methods br Results br
2020-06-08
Materials and methods Results Discussion Here we show expression of the EP1 receptor in the hippocampus of mice and the functional influence of the EP1 receptor on kainic Protionamide induced seizures. Mice lacking a functional EP1 receptor gene displayed a lower tendency to enter status e
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br Disclosures br Acknowledgements This work
2020-06-08
Disclosures Acknowledgements This work was supported by the Natural Science Foundation of China (No. 81560587); the Fok Ying-Tong Education Foundation of China (No. 151107), the basic ability promotion project for young and middle-aged teachers in Universities in Guangxi (No. 2018KY1146) and t
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br Materials and methods br Results br Discussion Innate imm
2020-06-08
Materials and methods Results Discussion Innate immunity plays an essential role in the control and elimination of bacterial infection through production of inflammatory cytokines (Liu et al., 2015). Production of inflammatory cytokines requires the recognition of bacterial pathogen-associa
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aminopeptidase Further indirect evidence supporting an impor
2020-06-08
Further indirect evidence supporting an important role of DPP-4 in the modulating the actions of both incretins comes from the observations that analogues of GLP-1 and GIP, modified to be resistant to DPP-4 cleavage, were subsequently shown to have greater metabolic stability in vivo which was assoc
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br Conclusion The role of
2020-06-08
Conclusion The role of DNA-PK target in DNA DSB repair renders this GSK126 kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were applied for design of p
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