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It has been reported that Eph
2020-08-10
It has been reported that Eph/Ephrin are involved in the regulation of the tumor angiogenesis [10], [11], [12]. The distinct and specific involvement of Liproxstatin-1 sale and veins in tumor angiogenesis is unclear. EphrinB2 is expressed in arteries and its receptor EphB4 is expressed in veins; th
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br Materials and methods br
2020-08-10
Materials and methods Results Discussion Endothelial cells are crucial for both vascular homeostasis and protecting the vasculature against atherogenic insults [3]. OxLDL-mediated injury to endothelial cells is crucial for endothelial dysfunction in the pathogenesis of atherosclerosis and a
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br Material and methods br Results br
2020-08-10
Material and methods Results Discussion A. fumigatus utilizes several virulence factors that facilitate its establishment in human hosts. Among these factors, the best known are hydrolytic enzymes such as proteases and phospholipases, toxins, melanine and catalases that neutralize the react
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Mouse Cyp a is a homologous isoform of the
2020-08-10
Mouse Cyp3a11 is a homologous isoform of the human CYP3A4 gene, and both are highly expressed in the liver (Hart, Cui, Klaassen, & Zhong, 2009). CYP3A4 is the most abundant CYP450 in hepatic microsomes responsible for drug and xenobiotic metabolism (Zanger & Schwab, 2013), and it is the most active
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Hydroxylated fatty acids such as ricinoleate
2020-08-07
Hydroxylated fatty acids such as ricinoleate (C18:1-OH) are important oleochemicals since they allow many chemical conversions to be carried out. Lesquerolic MnTBAP Chloride (C20:1-OH), synthesized by Lesquerella fendleri (Brassicaceae), is considered a new domestic raw material in the United State
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As carbonic anhydrase catalyzes the reaction
2020-08-07
As carbonic anhydrase catalyzes the reaction of CO2 and H2O to HCO3− and H+, a cost-effective means of capturing CO2 from industrial emitters, such as coal power plants using carbonic anhydrase have also been studied [31]. CO2 is fixed as HCO3- in aqueous media with carbonic anhydrase, and it can be
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We recently reported that DGK is
2020-08-06
We recently reported that DGKη1 is required for the Ras/B-Raf/C-Raf/MEK/ERK signaling cascade to be activated by epidermal growth factor (EGF) in HeLa cervical cancer cells [17]. Importantly, DGKη regulates the recruitment of B-Raf and C-Raf from the cytosol to membranes and controls their heterodim
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Further SAR studies will be carried out to
2020-08-06
Further SAR studies will be carried out to first optimize efficacy in vitro, and then to provide proof of concept activity in vivo. For in vitro activity against Leishmania, parasites within Triciribine will be used to ensure that compounds can enter the parasitophorous vacuoles within which parasi
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The enantiomeric ratio ER of
2020-08-06
The enantiomeric ratio (ER) of chiral compounds accumulated in organisms has been found to be different among species (Borga and Bidleman, 2005, Harner et al., 1999, Warner et al., 2005, Wiberg et al., 2000), indicating enantioselective accumulation of chiral compounds are species-specific. The ER o
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Compared to intracellular trafficking of ligand stimulated R
2020-08-06
Compared to intracellular trafficking of ligand-stimulated RTKs, the trafficking of unstimulated/basal RTKs is less understood. In the absence of CSF-1, CSF-1R has been shown to undergo constitutive internalization and basal recycling at a relatively low rate [24]. An understanding of the mechanisms
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PEGylation can be combined with
2020-08-06
PEGylation can be combined with other strategies to improve drug delivery. For example, it has been used in conjunction with niosomes, i.e. non-ionic surfactant-based vesicles that can carry various drugs within them, to improve cell targeting. Niosomes are first rendered magnetic with Fe3O4@SiO2 na
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br Materials and methods br Results br Discussion Homologs o
2020-08-06
Materials and methods Results Discussion Homologs of the N. crassa Ndr kinase COT-1 are important for cell differentiation and polar morphogenesis in various fungi (Buhr et al., 1996, Dürrenberger and Kronstad, 1999, Johns et al., 2006, Kodama et al., 2017, McNemar and Fonzi, 2002, Scheffer
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Rheological durability and fresh properties of cement grouts
2020-08-06
Rheological, durability, and fresh properties of cement grouts are generally improved by using chemical and mineral admixtures. Adding RS-1 to the grout at different compositions changes the hardened and the rheological properties of grouts. For different kinds of grout applications different addit
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The wide range of biological roles attributed to cPLA has
2020-08-06
The wide range of biological roles attributed to cPLA2α has been extended by recent work implicating this enzyme in the selective production of lipid mediators during macrophage polarization to either M1 (pro-inflammatory) or M2 (anti-inflammatory) states. A recent study investigated the synthesis o
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As before all calculations are
2020-08-06
As before [3], [4], all calculations are based on thermodynamically first- and second-order hydropathic (amino acid) scales [6], [7], linearly scaled to a common center and a common range for each of the 20 amino acids. These are then converted to a triangular matrix , where is the length of a s
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