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br Materials and methods br Results br Discussion Cardiac
2020-07-28
Materials and methods Results Discussion Cardiac hypertrophy is characterized by an increased cardiomyocyte size, excess protein synthesis, and thickened ventricular walls. Although myocardiac hypertrophy initially might be adaptive and compensatory, a sustained pathological hypertrophic re
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put away The use of recombinant ER
2020-07-27
The use of recombinant ERα and ERβ binding assays offers a relatively inexpensive, rapid technique for screening compounds for potential direct put away receptor modulatory activity and understanding the mechanisms of existing herbal medicines. For background on the protein production system used t
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The following are the supplementary data related
2020-07-27
The following are the supplementary data related to this article. Acknowledgement This project was supported by Sichuan Provincial Health and Family Planning Commission (No. 17PJ551). Introduction Type 2 diabetes is one of the greatest impending global health concerns. To date 415 million pe
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Matrix metalloproteinase MMP an effector and indicator molec
2020-07-27
Matrix metalloproteinase (MMP), an ion channel and indicator molecule in pathological state that provides cartilage health under both physiological circumstances and osteoarthritic state, which have already been studied earlier [52]. Collagen type II molecules is released upon joint injury that coul
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br Materials and methods Restriction endonucleases
2020-07-27
Materials and methods Restriction endonucleases, T4 DNA polymerase, Taq polymerase and a DNA ligation kit were purchased from Takara Shuzo, [α-32P]dCTP (3000 Ci/mmol) and a DNA sequencing kit were from Amersham, a Gene Clean II kit was from Bio 101, plasmid vector pET-3a was from Novagen, marker
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br Development and germination of cereal seeds Caryopses
2020-07-27
Development and germination of cereal seeds Caryopses (cereal grains) are the propagation units of many monocot species, such as wheat, triticale, barley and other cereal species. A caryopsis is a type of dry fruit composed of three tissues: the diploid embryo, the triploid endosperm and the mate
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Corticosteroids and adrenergic receptor agonists have
2020-07-27
Corticosteroids and adrenergic β2 receptor agonists have been clinically used as effective pharmacotherapy for asthma. In this study, asthmatic response in both S-hexyl GSH-non-treated and treated animals was attenuated by single treatment with dexamethasone or salmeterol. Combination treatment with
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n Butylphthalide NBP is a pure component of the
2020-07-27
3-n-Butylphthalide (NBP) is a pure component of the seed extract from Apium graveolens Linn (Chinese celery) [18]. It was approved by the State Food and Drug Administration (SFDA) of China for the treatment of cerebral ischemia in 2004 [19]. It has been reported that NBP is able to confer neuroprote
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br Drug ligand binding pockets Liao and
2020-07-27
Drug-ligand binding pockets Liao [76] and van Linden et al. [77] divided the region between the protein kinase small and large lobes into the front cleft or front pocket, the gate area, and the back cleft. The gate area and back cleft make up the back pocket or hydrophobic pocket II (HPII) (Fig.
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As mentioned above the quality of the education received
2020-07-27
As mentioned above, the quality of the education received at a particular institution should be considered a primary driver of the potential success of the students in passing the CPA exam. Besides accreditation, another indicator of academic quality is the selectivity of an institution when determi
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Although retention effects might stem
2020-07-27
Although retention effects might stem from differences in both consolidation and/or recall of extinction memory, prefrontal dopamine – and thereby COMT enzyme cathepsin g – might be particularly relevant for consolidation as indicated by studies on endogenous prefrontal dopamine release in rats aft
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CPH models reported usually as lists of
2020-07-25
CPH models, reported usually as lists of risk factors along with their parameters, are prevalent in medical literature. One such model is the CPH model created for the purpose of predicting the probability of one year survival of patients suffering from Pulmonary Arterial Hypertension [5]. The model
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AMD3100 br COTSget based Architectures This section
2020-07-25
COTSget-based Architectures This section describes how our COTSget-based architectures are defined. We use a design inspired by MDE to build a Domain-Specific Language (DSL) of the architecture, as can be seen in the metamodel of Fig. 3. This metamodel defines the abstract syntax of our DSL and i
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CK enzymes belong to a conserved family
2020-07-25
CK1 enzymes belong to a conserved family of serine/threonine protein kinases that plays an important and diverse role in vesicular trafficking, DNA repair, Fluconazole progression and cytokinesis in organisms from yeast to humans [15]. In multicellular organisms CK1 enzymes also regulate development
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These findings further extend our knowledge of how
2020-07-25
These findings further extend our knowledge of how P4 and/or E2 can mediate anxiety and fear responses. Female rats in behavioral estrous and ovx rats administered systemic P4 and/or E2 demonstrated significantly less anxiety in the open field and/or elevated plus maze, compared to diestrous rats, a
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