• MiR has already been implicated in the protective

  2024-08-14

  

  MiR-21 has already been implicated in the protective effects of Res on lung fibrosis, but the molecular mechanisms are underexplored. Our results showed a clear increase of activation protein 1 (AP-1) activity after TGF-β treatment, which was suppressed by Res in a dose-dependent manner, suggesting

• AP plays a pivotal role in

  2024-08-14

  

  AP-1 plays a pivotal role in transcriptional regulation of MMP expression. The decoy technique allows the neutralization of AP-1 without any transfection reagents for cellular uptake that cause potential side effects or immune reactions. This energy-dependent transport mechanism of “naked” dODN is c

• Analysis of the crystal structures of LAPs from

  2024-08-13

  

  Analysis of the crystal structures of LAPs from E. coli[29], bovine eye lens [30], Pseudomonas putida[27], tomato [31] and P. falciparum[32] revealed that the monomer of M17-family LAP is composed of two domains: the smaller, variable N-terminal domain and the larger, conserved C-terminal domain tha

• br Introduction Alcohol i e ethanol is absorbed into the

  2024-08-13

  

  Introduction Alcohol, i.e., ethanol, is absorbed into the blood from the stomach to the small intestine, then distributed throughout the body. The metabolism of alcohol converting to acetic BHQ sale basically involves two enzymes; alcohol dehydrogenase converting ethanol to acetaldehyde and aldeh

• The random zero offset of accelerometer and gyroscope estima

  2024-08-13

  

  The random zero offset of accelerometer and gyroscope estimated by two-step observation update Kalman filter are shown in Table 2, one group of estimated results is shown in Fig. 3. Contrast with the data from Eq. (23) and the ones from Fig. 3 and Table 2, it can be seen that the random zero offset

• One study has demonstrated that PUFA reduced

  2024-08-13

  

  One study has demonstrated that ω-3 PUFA reduced both cholesterol and caveolin-1 (a marker of raft), thereby displacing raft-associated signaling molecules from lipid raft [36]. Additionally, DHA treatment decreased the amount of lipid raft in the cell surface and displaced several lipid raft-associ

• We used the lead compound

  2024-08-13

  

  We used the lead compound C4 to demonstrate that small molecule ACL inhibitors can recapitulate ACL knockdown (KD) in modulation of cancer stemness. We have shown previously that ACL KD reduced the CSC population in multiple cancer cell lines. The E-snail cells are an established CSC model system.

• These anatomical studies were followed by the first function

  2024-08-13

  

  These anatomical studies were followed by the first functional MRI studies of auditory processing in songbirds that were performed in starlings (Van Meir et al., 2005; De Groof et al., 2017; De Groof et al., 2013b) and in zebra finches (Boumans et al., 2008a; Boumans et al., 2007; Boumans et al., 20

• Non steroidal anti inflammatory drugs which include aspirin

  2024-08-13

  

  Non-steroidal anti-inflammatory drugs, which include aspirin and ibuprofen, target COX-2 activity to inhibit inflammation. It has been shown that daily use of a nonsteroidal anti-inflammatory drugs is associated with reduced ER-positive breast cancer recurrence in obese and overweight women. More pr

• br The pathogenesis of AD

  2024-08-12

  

  The pathogenesis of AD and the targets of apelin Alzheimer's drugs Conclusions Introduction APJ, first identified from a human genomic library in 1993, belongs to a member of seven trans-membrane G protein-coupled receptor family. Its amino CGP 35348 sequence has 31% homology with that o

• A previous review article suggested different washout interv

  2024-08-12

  

  A previous review article suggested different washout intervals based on specific clinical contexts [4]. While no consensus was reached for the optimal interval between last dose of BV and surgery for CRLM, the authors of the review suggested waiting 6 to 8 weeks after BV before surgery, particularl

• br Eprosartan The AT R antagonist eprosartan is

  2024-08-12

  

  Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential Adenosine Kinase Inhibitor hydrate and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cer

• In addition to differential expression of AR protein primari

  2024-08-12

  

  In addition to differential expression of AR protein primarily in surgical specimens, genetic alterations involving the AR gene have been documented in human 1530 synthesis cancer. Loss of heterozygosity at the AR locus was identified in all 3 informative cases of muscle-invasive bladder tumors, whe

• br Selective Androgen Receptor Modulators SARMs The AR and i

  2024-08-12

  

  Selective Androgen Receptor Modulators (SARMs) The AR and its endogenous ligands, androgens, are important for development and maintenance of muscle and bone, secondary sexual organs, and development of other tissues (Mooradian et al., 1987). Although androgens are important for normal developmen

• A has been reported to decrease

  2024-08-12

  

  Aβ has been reported to decrease insulin receptors and impair insulin signaling in neurons, preventing phosphorylation of Akt and glycogen synthase kinase 3β (GSK-3β), downstream of insulin signaling, and to increase phosphorylation of tau protein causing neurofibrillary tangles (Tokutake et al., 20

15884 records 90/1059 page Previous Next First page 上5页 8687888990 下5页 Last page