• Findings from the present study

  2019-07-02

  

  Findings from the present study indicate that CRF1 receptors are especially important in fear acquisition. CP154,526 given before acquisition training, at least partly, reinstated the fear-potentiated startle response and blocked the development of contextual conditioned fear in SERT−/− rats. CP154,

• One possible pitfall of using EPAC activators in the

  2019-07-02

  

  One possible pitfall of using EPAC2 activators in the treatment of T2DM is their potential to increase glucagon levels. As discussed previously, although the ability of EPAC2 to increase glucagon expression and production is controversial, several studies show that this protein increases Gcg mRNA le

• Another important new result that

  2019-07-02

  

  Another important new result that has expanded the range of functions of iPLA2-VIA in physiology and pathophysiology is its implication in macrophage polarization under stimulation conditions. Ashley et al. [129] described in peritoneal macrophages from Pla2g6−/− mice that the absence of iPLA2-VIA f

• We found that Th cells derived

  2019-07-02

  

  We found that Th17 cells, derived either from in vivo immunization or in vitro polarization under pathogenic conditions (in presence of IL-23 and/or IL-1β) expressed high levels of EBI2. In contrast, Th17 caudatin of that were generated in absence of IL-23 or IL-1β lost EBI2 expression during differ

• As discussed in the introduction many pregnant women take

  2019-07-01

  

  As discussed in the introduction, many pregnant women take medications such as nifedipine and indinavir, which are considerably metabolized by CYP3A [26]. Previous reports have also shown increased CYP3A activity following pregnancy [7], [9], which is consistent with our results. However, previous s

• The present study failed to demonstrate an independent assoc

  2019-07-01

  

  The present study failed to demonstrate an independent association of preoperative ChE with BCR. This is in contrast to Koie et al. who reported that pretreatment serum ChE was significantly associated with BCR in 535 patients with CaP who underwent RP (5-year BRFS rates were 77.7% and 55.0%, respec

• The characteristics of the tumors are shown in

  2019-07-01

  

  The characteristics of the tumors are shown in Table 2. The tumor morphology indicated 69 (74%) exophytic tumors and 24 (26%) endophytic tumors. Forty-five patients (48%) had anterior commissure invasion, and 30 (32%) had tumors extending to the contralateral true vocal fold. Twenty-two patients (24

• Pain flare defined as a temporary worsening of bone pain

  2019-07-01

  

  Pain flare, defined as a “temporary worsening of bone pain in the treated metastatic site” [2], has been previously documented as a side effect of radiopharmaceutical and hormonal therapy [2,10,11]. Although it is a recognized side-effect of radiation treatment as well, only recent studies have att

• br Conflict of interest br Authors contributions

  2019-07-01

  

  Conflict of interest Authors’ contributions Acknowledgements Introduction Aromatase-Inhibitors (AIs) are commonly used in the treatment of post-menopausal women with a history of hormone receptor-positive breast carcinoma, and have been shown to decrease bone mineral density (BMD) and in

• A substantial body of evidence linking inflammation to the p

  2019-07-01

  

  A substantial body of evidence linking inflammation to the pathophysiology of a broad spectrum of cardiovascular diseases, including coronary artery disease, diabetes mellitus, and hypertension, has been developed [8–11]. Similarly, the hypothesis that inflammatory processes are involved in the path

• br Genetic basis for atrial

  2019-07-01

  

  Genetic basis for atrial standstill Genetic basis of conduction block Genes involved in cardiac development and bradycardia Development of the CCS is a complex biological process with the potential to be wrought with problems. Several transcription factors, including homeodomain proteins an

• Introduction Catheter ablation of accessory pathways APs

  2019-07-01

  

  Introduction Catheter ablation of accessory pathways (APs) can be challenging depending on the location of the AP. Anteroseptal APs are rare but associated with lower success rates and higher incidence of atrioventricular (AV) block [1,2]. Data regarding the electrocardiographic and electrophysiolo

• br In Anand Bhopal s discussion March

  2019-07-01

  

  In Anand Bhopal\'s discussion (March, 2015) of health inequalities, social determinants of health, and advocacy for social change in health care in the 21st century, we were disappointed to see little recognition of the branch of medicine that dnmt epitomises “societal doctors”: public health. A

• Sirtinol En la condensaci n del Borges y yo

  2019-07-01

  

  En la condensación del “Borges y yo” se despliega un texto que tanto puede ser considerado perteneciente al orden de la narrativa como al orden del ensayo, e incluso al de la poesía. En palabras de José Miguel Oviedo, “es un cuento que es también un ensayo que es también un poema”. “No sé quién de l

• br Conflict of interest statement br

  2019-06-29

  

  Conflict of interest statement Acknowledgement We thank the constant support of nanomedicine research from the Ming Hsieh Institute for Research on Engineering-Medicine for Cancer. The authors certify that they have no affiliations with or involvement in any organization or entity with any fin

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