• Several culture techniques have been developed for

  2018-11-02

  

  Several culture techniques have been developed for ex vivo expansion of limbal epithelial cells, including those that used intact or denuded AM as a supporting matrix; adopted an airlifting technique to promote epithelial differentiation; and prepared 3T3 fibroblasts as feeder layers (Sun et al., 20

• GSK2656157 Although our report mainly focuses on the

  2018-11-02

  

  Although our report mainly focuses on the generation of clinical-grade hESCs, transplantation safety is also a concern. For example, a 9-year-old boy was diagnosed with a glioneuronal neoplasm after being transplanted with neural stem GSK2656157 derived from two donors (Amariglio et al., 2009). Alt

• For ESCs on the other

  2018-11-02

  

  For ESCs, on the other hand, we and others recently established that single factors, such as neurogenic differentiation factor 1 (NEUROD1) or neurogenin 2 (NGN2), alone are sufficient to rapidly induce the neuronal fate (Thoma et al., 2012; Zhang et al., 2013). In fibroblasts, however, we had origin

• Taken together our results demonstrate an essential role for

  2018-11-02

  

  Taken together, our results demonstrate an essential role for STAT5 in the regulation of adult IESC homeostasis and response to intestinal injury and regeneration. Functionally, genetic activation of Stat5 increases IESC regeneration to replenish injured intestinal epithelia, conferring resistance t

• The addition of only g ml rBC LCN PE

  2018-11-02

  

  The addition of only 10 μg/ml rBC2LCN-PE23 to the culture medium was sufficient to completely eliminate hiPSCs after 24 hr, even in a mixed cell population. The dispersion of colonies was not a prerequisite to induce cell death of hiPSCs, demonstrating the high permeation ability of the developed re

• The creation and maintenance of subcutaneous patient derived

  2018-11-02

  

  The creation and maintenance of subcutaneous patient-derived xenografts (PDX) from fresh or cryopreserved ACC tissue (Moskaluk et al., 2011) provided a renewable source of ACC read the article for validation of our CSC hypothesis. As we previously demonstrated, these PDX models reproduced ACC morph

• In this study we describe an efficient dCas

  2018-11-02

  

  In this study, we describe an efficient dCas9 activator with multimeric VP16 activation domain and a simplified method for guide RNA assembly and cloning. We demonstrate that the dCas9 activator can be fused to a dihydrofolate reductase (DHFR)-derived destabilization domain (DD) (Iwamoto et al., 201

• The ISSCR has recently released updated guidelines on stem

  2018-11-02

  

  The ISSCR has recently released updated guidelines on stem cell research and clinical translation (Daley et al., 2016; ISSCR, 2016) that stress the importance of rigorous preclinical testing and recommends the publication of preclinical studies in full to allow assessment of the strength of the evid

• When it comes to the development of

  2018-11-02

  

  When it comes to the development of statistical radio engineering and radiophysics, Kotel\'nikov should be given credit where credit is due; we should point out, for historical accuracy, that in his monograph [2] he obtained, among other calculations, an example of a canonical decomposition, even th

• The mixture of pure nanoparticles of the

  2018-11-02

  

  The mixture of pure nanoparticles of the influenza virus (strain A1-H1N1) and albumin proteins (as an example of impurity) can be considered as a model of dispersions in the technological process of vaccine production. The influenza virus particle was approximated as a homogeneous sphere with the me

• br For the integral to be

  2018-11-02

  

  For the integral (8) to be finite we set the regularization parameter ξ equal to –1 at this stage. Then the Gauss integral (8) can be calculated without effort. The following simple example illustrates the regularization procedure proposed here (for ): The only irritant in our regularization pr

• To our knowledge this is the

  2018-11-02

  

  To our knowledge, this is the first study to empirically test the claim that flexicurity policies have the capacity to attenuate the adverse health consequences of temporary employment across a large sample of advanced capitalist countries. Prior studies have challenged the notion that flexicurity c

• Our findings also suggest that increase in contribution

  2018-11-02

  

  Our findings also suggest that increase in contribution of income to inequalities could be related to changes in the distribution of income within Canada and the United States. Recent work by Bernabé and Marcenes (2011) suggest the degree of state income inequality may be attributed to inequalities

• br Methods br Measures br

  2018-11-02

  

  Methods Measures Statistical analyses Data analysis was conducted at the [blinded] Research Data Centre using STATA statistical software (version 14) (Statacorp, College Station, TX, 2015). Marginal effect 4-ethylphenyl sulfate analyses were calculated to quantify the potential reduction i

• Research quantifying community capacity has identified

  2018-11-02

  

  Research quantifying buy Manumycin A capacity has identified statistically significant differences amongst neighbourhoods (Jung & Rhee, 2013) and between towns (Lovell et al., 2015a), thus confirming the importance of place to our social relationships. Place is recognised by geographers as those as

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